Dihydroartemisinin|71939-50-9|(双氢青蒿素; Dihydroqinghaosu; β-Dihydroartemisinin; Artenimol)-陌孚医药/Medlife

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Dihydroartemisinin (Synonyms: 双氢青蒿素; Dihydroqinghaosu; β-Dihydroartemisinin; Artenimol)

目录号: PC64068 纯度: ≥98.0%

CAS No. :71939-50-9

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中文名称	Dihydroartemisinin
中文别名	双氢青蒿素;双氢青蒿素(标准品);■双氢青蒿素;Dihydroartemisinin 双氢青蒿素;Dihydroartemisinin 双氢青蒿素标准品;青蒿素甲醚相关物质A;双氢青蒿素原药;(3R,5aS,6R,8aS,9R,12S,12Ar)-八氢 -3,6,9- 三甲基 -3,12-桥氧-12 H-吡喃 [4,3-j]-1,2 苯并二塞平-10(3H)-酮;双氢青素
英文名称	Dihydroartemisinin
英文别名	(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol;(3r,5as,6r,8as,9r,10r,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10-ol;(3r,5as,6r,8as,9r,10s,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10-ol;Dihydroarteminisin;Dihydroartemisin;Alaxin;b-Dihydroartemisinin;Cotecxin;Dihydro Artemisinin;Dihydroartemisinin,mixture of α and β isomers;(3R,5aS,6R,8aS,9R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol;(3R,5aS,6R,8aS,9R,12S,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol;Cotexin;DHA;DHQHS 2;Dihydroginghaosu;Dihydroqinghaosu;dihydroquinghaosu;dihyhydroartemisinin;Salaxin;β-Dihydroartemisinin;(3R,5aS,6R,8aS,9R,12R,12aR)-Decahydro-10-hydroxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin;Dihydroartemisinin;BN0685;(1S,5R,9R,12R,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol;Dihydro Artemisinin (a,? Mixture);BBL033188;STL146329;SY058680;A916373;Q5276420
Cas No.	71939-50-9
分子式	C₁₅H₂₄O₅
分子量	284.35
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

Dihydroartemisinin is a potent anti-malaria agent.

性状

Solid

IC50 & Target[1][2]

RelA
Plasmodium

体外研究(In Vitro)

Dihydroartemisinin (DHA) is an antimalarial agent. Dihydroartemisinin treatment effectively up-regulates the cytosolic RelA/p65 protein level and down-regulates the nuclear RelA/p65 protein level. Dihydroartemisinin blocks the nuclear translocation of RelA/p65 from the cytosol rather than suppressing RelA/p65 protein synthesis. Dihydroartemisinin induces autophagy in RPMI 8226 cells. Dihydroartemisinin suppresses NF-κB activation in RPMI 8226 cells. The NF-κB Dihydroartemisinin -binding activity is examined by EMSA assay. RPMI 8226 cells are exposed to various concentrations of Dihydroartemisinin (10, 20 and 40 μM) for 12 h, and TNF-α is introduced as a positive control for NF-κB activation. Dihydroartemisinin suppresses NF-κB activation in a dose-dependent manner in contrast with TNF-α. Dihydroartemisinin (DHA) can enhance the anti-tumor effect of photodynamic therapy (PDT) o

体内研究(In Vivo)

Single oral doses of Dihydroartemisinin (at 200, 300, 400 or 600 mg/kg), given once on each of day 6-8 post-infection, reduce total-worm burdens by 69.2%-90.6% and female-worm burdens by 62.2%-92.2%, depending on dosage in the first experiment. Similar treatments given on day 34-36 post-infection reduce total-worm burdens by 73.9%-85.5% and female-worm burdens by 83.8%-95.3%.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Terpenoids
Sesqui

来源

Plants

溶解度数据	体外研究: DMSO : 25 mg/mL(87.92 mM;Need ultrasonic) Ethanol : 10 mg/mL(35.17 mM;Need ultrasonic) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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