Anabasine|494-52-0|((+)-假木贼碱; (S)-Anabasine; (+)-Anabasine)-陌孚医药/Medlife

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Anabasine (Synonyms: (+)-假木贼碱; (S)-Anabasine; (+)-Anabasine)

目录号: PC62946 纯度: ≥99%

CAS No. :494-52-0

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中文名称	Anabasine
中文别名	L(-)-八角枫碱;(-)-毒藜碱;(-)-假木贼碱;2-(3-吡啶基)哌啶;S-假木贼碱;硫苯咪唑砜;尼古丁相关化合物G USP标准品;尼古丁杂质G;尼古丁杂质G(EP) 标准品;新烟碱;3-(2-哌啶基)吡啶;阿拉巴新碱;毒藜碱;假木贼碱;灭虫碱;新烟;L-(-)-假木贼碱;(-)-2-(3'-吡啶基)哌啶
英文名称	Anabasine
英文别名	(S)-3-(Piperidin-2-yl)pyridine;(-)-Anabasine;(-)-Neonicotine~(S)-3-(2-Piperidinyl)pyridine;3-(2-Piperidyl)-pyridine;2-(3-pyridyl)piperidine;(S)-Anabasine;Anabasine;3-(2S)-2-piperidinylpyridine;3-[(2S)-2-piperidyl]pyridine;3-[(2S)-piperidin-2-yl]pyridine;neonicotine;(-)-2-(3'-Pyridyl)piperidine;Neonikotin;Anabasin;Anabazin;S-(-)-Anabasine;L-3-(2'-Piperidyl)pyridine;Pyridine, 3-(2-piperidyl)-;Piperidine, 2-(3-pyridyl)-;L-(-)-Anabasine;(S)-(-)-Anabasine;Pyridine, 3-(2S)-2-piperidinyl-;LMS11II2LO;MTXSIJUGVMTTMU-JTQLQIEISA-N;2-(3'-Pyridyl) piperidine;Pyridine, 3-(2-piperidinyl)-, (S)-;Caswell N
Cas No.	494-52-0
分子式	C₁₀H₁₄N₂
分子量	162.23
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性	Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC₅₀=0.7 μM).
性状	Liquid
IC50 & Target[1][2]	nicotinic receptor
体内研究(In Vivo)	Anabasine significantly reverses the impairment at the 0.2 mg/kg (p<0.05) and 2 mg/kg doses (p<0.025). Anabasine does not have any significant effects on response latency when administered alone. The 0.06 mg/kg Anabasine dose, in fact, significantly (p<0.05) exacerbates the dizocilpine-induced impairment. None of these Anabasine doses affects choice accuracy on their own. Individual dose comparisons show that the 0.06 mg/kg Anabasine dose plus dizocilpine (6.7±2.6) causes a significant (p<0.05) increase in non-response trials compare with dizocilpine alone (2.1±0.8).Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；
结构分类	Alkaloids Pyridin
来源	Plants

溶解度数据	体外研究: DMSO : 100 mg/mL(616.41 mM;Need ultrasonic) 配制储存液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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