Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities.

Solid

Girinimbine (1-400 μM; 24-72 h) decreases the viability of HepG2 cells in 24, 48 and 72 h with IC50 values of 61 μM, 56 μM, and 40 μM respectively. Girinimbine (10-100 μM; 24-48 h) increase of LDH leakage in both concentration- and time-dependent manner in HepG2 cells.
Girinimbine (56 μM; 24-48 h) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells.HepG2 cells.
Girinimbine (56 μM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest.
Girinimbine shows a potent antitrypanosomal activitywith an IC50 value of 10.16 μg/mL.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid.
In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
dy>

Room temperature or refrigerated transport.

4°C, Sealed and stored away from moisture and light；*In solvent : -80°C, 6 months; -20°C, 1 month (Sealed and stored away from moisture and light)；

Alkaloids
Indole

Plants