Rauwolscine hydrochloride|6211-32-1|(萝芙素盐酸盐; α-Yohimbine hydrochloride; Corynanthidine hydrochloride; Isoyohimbine hydrochloride)-陌孚医药/Medlife

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Rauwolscine hydrochloride (Synonyms: 萝芙素盐酸盐; α-Yohimbine hydrochloride; Corynanthidine hydrochloride; Isoyohimbine hydrochloride)

目录号: PC62991 纯度: ≥98.0%

CAS No. :6211-32-1

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中文名称	Rauwolscine hydrochloride
中文别名	育亨宾碱;萝芙素盐酸盐;盐酸育亨宾;ALPHA-盐酸育亨宾;萝芙素
英文名称	Rauwolscine hydrochloride
英文别名	Yohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, hydrochloride (1:1), (16b,17a,20a)-;Rauwolscine Hydrochloride;Rauwolscine (hydrochloride);Rauwolscine • HCl;RAUWOLSCINE HCL;YOHIMBINE HCL, ALPHA-(RAUWOLSCINE HCL)(RG);YOHIMBINE HCL, ALPHA-(RAUWOLSCINE HCL)(RG) PrintBack;ISOYOHIMBINE;MESOYOHIMBINE;RAUWOLFSCINE HYDROCHLORIDE;RAUWOLSCINE;alpha-Yohimbine hydrochloride;Methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate hydrochloride
Cas No.	6211-32-1
分子式	C₂₁H₂₆N₂O₃^.ClH
分子量	390.90
包装储存	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性	Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a K_i of 12 nM.
性状	Solid
IC50 & Target[1][2]	Ki: 12 nM (α2 adrenergic receptor)
体外研究(In Vitro)	[H]Rauwolscine binding to α2 adrenergic receptor is reversible, stcreospccific, and saturable. [H]Rauwolscine specifically labels both the high and low affinity states of the α2 adrenergic receptor in brain membranes. [H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors. When using [H]5-HT as a radioligand, rauwolscine is determined to have relatively high affinity for the human receptor (Ki human=14.3 nM, Ki rat=35.8 nM). Saturation studies shows that the affinity of [H]Rauwolscine is similar in mouse, rat, rabbit, dog (2.33-3.03 nM) except man where it is significantly higher (0.98 nM) .Medlife has not independently confirme
运输条件	Room temperature or refrigerated transport.
储存方式	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；
结构分类	Alkaloids Indole
来源	Plants other fami

溶解度数据	体外研究: DMSO : 6 mg/mL(15.35 mM;Need ultrasonic) H₂O : 5 mg/mL(12.79 mM;Need ultrasonic) 配制储存液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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