Puromycin dihydrochloride|58-58-2|(嘌呤霉素二盐酸盐; CL13900 dihydrochloride)-陌孚医药/Medlife

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Puromycin dihydrochloride (Synonyms: 嘌呤霉素二盐酸盐; CL13900 dihydrochloride)

目录号: PC61233 纯度: ≥99%

CAS No. :58-58-2

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中文名称	Puromycin dihydrochloride
中文别名	嘌呤霉素二盐酸盐;嘌呤霉素盐酸盐;Puromycin 嘌呤霉素;二盐酸嘌呤霉素;嘌呤霉素;嘌呤霉素,2HCl;嘌呤霉素二盐酸盐水合物;二氢氯化嘌呤毒素;嘌呤霉素,二盐酸
英文名称	Puromycin dihydrochloride
英文别名	Adenosine,3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-,hydrochloride (1:2);Puromycin Dihydrochloride;Adenosine,3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-,hydr...;CL13900 dihydrochloride;Purine, 6-dimethylamino-9-[3-(p-methoxy-L-phenylalanylamino)-3-deoxy-.β.-D-ribofuranosyl]-, dihydrochloride;Puromycin (hydrochloride);Puromycin . 2HCl;Puromycin Dihydrochl;Puromycin dihydrochloride (CL 13900);Puromycin;dihydrochloride;PuroMycin dihydrochloride hydrate;Puromycin (S)-3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride;B7587;(2S)-2-Amino-N-[(2S,3R,4S,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl
Cas No.	58-58-2
分子式	C₂₂H₃₁Cl₂N₇O₅
分子量	544.43
包装储存	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性	Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis.
性状	Solid
IC50 & Target[1][2]	Aminoglycoside

体外研究(In Vitro)

Puromycin blocks protein synthesis after aminoacyl-sRNA formation, and at the same time it leads to the accumulation of small peptides. Both of these effects appear to be due to the splitting of ribosome-bound peptidyl-sRNA,4 which results in release of incomplete peptide chains..
Puromycin, an analog of the 3 end of aminoacyl-tRNA, causes premature termination of translation by being linked non-specifically to growing polypeptide chains. Puromycin has two modes of inhibitory action. The first is by acting as an acceptor substrate which attacks peptidyl-tRNA in the P site to form a nascent peptide. The second is by competing with aminoacyl-tRNA for binding to the A site.
When used in minimal amounts, puromycin incorporation in neosynthesized proteins reflects directly the rate of mRNA translation in vitro. Puromycin immunodetection is an advantageous alternativ

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

结构分类

Antibiotics
Other

来源

Streptomyces alboniger

溶解度数据	体外研究: H₂O : 50 mg/mL(91.84 mM;Need ultrasonic and warming) DMSO : 50 mg/mL(91.84 mM;Need ultrasonic) Ethanol : 5 mg/mL(9.18 mM;ultrasonic and warming and heat to 60°C)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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