Monensin sodium salt|22373-78-0|(Monensin A sodium)-陌孚医药/Medlife

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Monensin sodium salt (Synonyms: Monensin A sodium)

目录号: PC61255 纯度: ≥98.0%

CAS No. :22373-78-0

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中文名称	Monensin sodium salt
中文别名	莫能霉素钠盐;金叶树苷;莫能菌素;莫能菌素钠盐;莫能菌素钠;莫能霉素钠;莫能菌素钠 (兽药);孟宁素、摩能霉素钠;莫能菌酸钠;莫能菌素钠盐 USP标准品;莫能菌素钠盐标准品;莫能霉素钠水合物标准品;莫能霉素钠盐原药;Monensin sodium莫能霉素钠
英文名称	Monensin sodium salt
英文别名	Monensin Sodium;Monesin Sodium;1,6-Dioxaspiro[4.5]decane-7-butyricacid,2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-.beta.-methoxy-.alpha.,.gamma.-2,8-tetramethyl-,monosodiumsal;1,6-Dioxaspiro[4.5]decane-7-butyricacid,2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-.beta.-methoxy-.alpha.,.gamma.-2,8-tetramethyl-,monosodiumsalt;Coban;Coban45;methyl-5-(tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2h-pyran-2-yl)-2;monensin,monosodiumsalt;Monensin,monosodiumsalt(9CI);Monensin sodium salt;Monensin (sodium salt);Monensin sodium salt hydrate;Monensin, sodium salt （Monensin A, sodium salt）;4-Mercaptopyridine;Monensim A sodium salt;monensin A sodium;Monensin A sodium salt;Monensin Sodium (200 mg);Monensin, Sodium Salt (high purity);MONENSINSODIUM,USP;RUMENSIN;Sodium Monensin;1,6-Dioxaspiro[4.5]decane-7-butyricacid,2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-b-methoxy-a,g,2,8-tetramethyl-, monosodium salt (8CI);CRC Rumensin;NSC 343257;Monensin,monosodium salt (9CI);Coban 45;Monensin sodium salt
Cas No.	22373-78-0
分子式	C₃₆H₆₁O₁₁-^.Na+
分子量	692.85
包装储存	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性	Monensin sodium salt is an antibiotic secreted by the bacteria Streptomyces cinnamonensis. Monensin sodium salt is an ionophore that mediates Na/H exchange. Monensin sodium salt causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion.
性状	Solid
IC50 & Target[1][2]	bacterial
体外研究(In Vitro)	Monensin sodium salt is an antibiotic secreted by the bacteria Streptomyces cinnamonensis. Untreated cells display 2.5% apoptosis; 48 hours treatment with 1 μM Monensin sodium salt shows 4.5% apoptosis whereas 5 μM Monensin sodium salt for 48 hours induces a greater apoptotic response (16.4%). Pretreatment with either 1 or 5 μM Monensin sodium salt for 24 hours followed by 10 μM erlotinib treatment for another 24 hours results in a marked increases in apoptotic events (14.6% and 38.7%, respectively) when compare with either Monensin sodium salt or erlotinib treatments alone. Combination of 5 μM Monensin sodium salt with 10 μM erlotinib shows the highest percentage of apoptosis (38.7%).Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Although the numbers of tumors do not change substantially, a significant (P=0.0144) reduction in the average size of lesions is observed in Monensin sodium salt-treated Apc mice when compare with control animals (mean 0.199 mm vs. 0.299 mm). The total tumor area estimated in one animal is decreased in individuals receiving Monensin sodium salt (mean 10.16 mm vs. 16.46 mm; P=0.0125). Monensin sodium salt treatment increases the numbers of apoptotic cells and cells expressing the p21 cell-cycle inhibitor at the surface area of the neoplastic outgrowths. No changes in the cell proliferation, differentiation, and tissue architecture in the healthy parts of mucosa are noted after exposure to Monensin sodium salt.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；
结构分类	Antibiotics Other
来源	Streptomyces spp

溶解度数据	体外研究: Ethanol : 20 mg/mL(28.87 mM;Need ultrasonic) DMSO : 5.4 mg/mL(7.79 mM;Need ultrasonic) 配制储存液

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