α-亚麻酸|463-40-1

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α-Linolenic acid (Synonyms: α-亚麻酸;ALA;C18:3 n-3;C18:3 (9Z,12Z,15Z);FA 18:3)

目录号: PC61691 纯度: ≥99%

CAS No. :463-40-1

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中文名称	α-Linolenic acid
中文别名	亚麻酸;α-亚麻酸;A-亚麻酸;Α-亚麻酸原液(游离酸);全顺式-9,12,15-十八碳三烯酸;9,12,15-十八碳三烯酸;alpha-亚麻酸;次亚麻子酸;a-亚麻酸α-亚麻酸;Linolenic Acid 亚麻酸;α-Linolenic acid α-亚麻酸标准品;γ-亚麻酸;亚麻酸(ALA)(AS);亚麻酸(linolenic acid );(顺,顺,顺)-9,12,15-十八碳三烯酸;9,12,15-三烯十八酸;α-亚麻酸(C18:3)标准品;次亚麻子油酸;十八碳三烯酸(顺-9,12,15);亚麻酸,certified 标准品;亚麻油酸;顺,顺,顺-9,12,15-十八碳三烯酸;顺9-顺 12-顺 15-十八碳三烯酸
英文名称	α-Linolenic acid
英文别名	(9Z,12Z,15Z)-Octadeca-9,12,15-trienoic acid;OCTADECA-9Z,12Z,15Z-TRIENOIC ACID;(Z,Z,Z)-9,12,15-Octadecatrienoic acid;9,12,15-OCTADECATRIENIC ACID;9,12,15-OCTADECATRIENOIC ACID;9Z,12Z,15Z-OCTADECATRIENOIC ACID;ALPHA-LINOLENIC ACID;ALPHA-LNN;ALL CIS-9,12,15-OCTADECATRIENOIC ACID;α-Linolenic acid;9-cis,12-cis,15-cis-Octadecatrienoic acid;Linolenic acid;LINOLENIC ACID(ALA)(AS) PrintBack;(9Z,12Z)-1,3-dihydroxypropan-2-yl octadeca-9,12-dienoate;(9Z,12Z,15Z)-linolenic acid;2-Linoleoylglycerol;2-linoleoyl-sn-glycerol;2-Monolinolein;8,11,14-Heptadecatriene-1-carboxylic acid;9,12-Octadecadienoic acid (Z,Z)-,2-hydroxy-1-(hydroxymethyl)ethyl ester;9Z,12Z,15Z-octadecatrienic acid;alpha;C18:3 (9,12,15-cis all);Glyceryl 2-linoleate;linoleic acid monoacylglycerol;octadecatrienoic acid;α-Lnn;9,12,15-all-cis-Octadecatrienoic acid;Perilla seed oil;linolenate;a-Linolenic acid;9,12,15-Octadecatrienoic acid, (Z,Z,Z)-;(9,12,15)-linolenic acid;Linolenic acid (8CI);Industrene 120;(9Z,12Z,15Z)-Octadecatrienoic acid;UNII
Cas No.	463-40-1
分子式	C₁₈H₃₀O₂
分子量	278.43
包装储存	-20°C, stored under nitrogen；*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)；

产品详情	α-Linolenic acid (ALA) is an essential ω-3 polyunsaturated fatty acid found in plants.[1] It is converted to the longer-chain fatty acids eicosapentaenoic (Item Nos. 90110 \| 90110.1 \| 21908), docosapentaenoic (Item Nos. 90165 \| 21907), and docosahexaenoic acid (Item No. 90310).[2] It is also catabolized via fatty acid β-oxidation for energy or the synthesis of saturated and monounsaturated fatty acids, or stored in adipose tissue. Dietary consumption of α-linolenic acid-containing foods is positively associated with a moderately lower risk of cardiovascular disease.[1]
生物活性	α-Linolenic acid, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer.
性状	Liquid
IC50 & Target[1][2]	PI3K;Akt
体外研究(In Vitro)	α-Linolenic acid converses into the longer chain fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	α-Linolenic acid (50, 100, 250 mg/kg; for 10 days) can completely inhibit collagen- and adrenaline-induced thrombosis in mice at 250 mg/kg. α-Linolenic acid (35, 70, 175 mg/kg) suppresses A-V thrombus formation in rats (weighing at 250?~?300 g). α-Linolenic acid (70 or 175 mg/kg) inhibits collagen stimulated platelet aggregation in rats. Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	-20°C, stored under nitrogen；*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)；
结构分类	Others
来源	Plants
参考文献	Product Description References 1. Pan, A., Chen, M., Chowdhury, R., et al. α-Linolenic acid and risk of cardiovascular disease: A systematic review and meta-analysis. Am. J. Clin. Nutr. 96(6), 1262-1273 (2012). 2. Burdge, G.C. Metabolism of α-linolenic acid in humans. Prostaglandins Leukot. Essent. Fatty Acids 75(3), 161-168 (2006). Product Citations Conlon, M., Poltorack, C.D., Forcina, G.C., et al. A compendium of kinetic modulatory profiles identifies ferroptosis regulators. Nat. Chem. Biol. (2021). Zou, Y., Li, H., Graham, E.T., et al. Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nat. Chem. Biol. 16(3), 302-309 (2020). Yamamoto, T., Matsui, H., Yamaji, K., et al. Narrow-spectrum inhibitors targeting an alternative menaquinone biosynthetic pathway of Helicobacter pylori. J. Infect. Chemother. 22(9), 587-595 (2016).

溶解度数据	体外研究: Ethanol : 100 mg/mL(359.16 mM;Need ultrasonic) DMSO : 100 mg/mL(359.16 mM;Need ultrasonic) H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) 0.15 M Tris-HCl pH 8.5: >1 mg/ml PBS (pH 7.2): <100 µg/ml

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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