G-418 disulfate|108321-42-2|(Geneticin sulfate; Antibiotic G-418 sulfate)-陌孚医药/Medlife

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G-418 disulfate (Synonyms: Geneticin sulfate; Antibiotic G-418 sulfate)

目录号: PC61234 纯度: 10mM*1mL in Water

CAS No. :108321-42-2

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中文名称	G-418 disulfate
中文别名	G-418 硫酸盐;硫酸G418;G418硫酸氢盐;G418硫酸盐;遗传霉素硫酸盐;(+)-薄荷醚氯;G-418硫酸盐溶液;G-450硫酸盐;G-451硫酸盐;丁香提取物;抗生素G418;抗生素G418,BR;庆大霉素二硫酸盐;D-葡萄糖酸溶液;G418二硫酸盐;公丁香提取物;抗菌素G-418;抗生物質G418;遗传霉素重硫酸盐G418硫酸盐细胞培养验证;硫酸氢盐;抗生物G418;遗传霉素重硫酸盐
英文名称	G-418 disulfate
英文别名	Geneticin;ANTIBIOTIC G-418 SULFATE;G-418 SULPHATE;G 418;G418 SULFATE;G418 SOLUTION;G418 DISULFATE CELL CULTURE TESTED;G418 DISULFATE PLANT CELL CULTURE TESTED;G418 Disulfate;G 418 disulfate salt;G-418 sulfate;G-418 disulfate salt;2-[4,6-diamino-3-[3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol,sulfuric acid;G418 sulfate (geneticin);Geneticin Disulfate Salt;Gentamicin C2 sulfate;Gentamicin disulfate;Antibiotic G418;D-Gluconic acid solution;G 418 Sulfate,Cell Culture Tested;G 418 Sulfate,Sterile-Filtered Aqueous Solution,Cell Culture Tested;G-418 Disulphate;G418 sulfate, for biocheMistry;Geneticin sulfate;Geneticin,G-418 Sulfate;O-2-Amino-2,7-dideoxy-Δ-glycero-α-Δ-glucoheptopyranosyl[1->4]-O-3-deoxy-4C-methyl-3-[methyl-amino]-β-L-arabinopyranosyl-Δ-streptamine, disulfate salt;G 418 disulfate salt solution;neomycin;G-418,Geneticin;G-418.SulfateSolid;Geneticin sulfate.;Geneticinedisulfate;620u/Mg;G-418 Geneticin\|G418 Sulfate;AK164211;(2S,5R)-2-[4,6-Diamino-3-[(2R,6S)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyc;CID 137705472;G-418 disulfate
Cas No.	108321-42-2
分子式	C₂₀H₄₄N₄O₁₈S₂
分子量	692.71
包装储存	4°C, stored under nitrogen, away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)；

生物活性	G-418 disulfate (Geneticin sulfate), is an aminoglycoside antibiotic, inhibits protein synthesis in eukaryotes and prokaryotes. G-418 disulfate is commonly used as a selective agent for eukaryotic cells.
性状	Solid
IC50 & Target[1][2]	Aminoglycoside

体外研究(In Vitro)

G418 sulfate, an aminoglycoside neomycin analogue, interferes with protein synthesis and has been used extensively for selection of mammalian cell lines that possess neomycin resistance (NR). The neomycin resistance (neo) gene is frequently used in eukaryotic vectors as a dominant selectable gene. G418 can be covalently bound to asialoorosomucoid (AsOR) to form a conjugate for hepatocyte-specific targeting and toxicity.
The human GD3 synthase cDNA was transfected into MDA-MB231 cells, and G-418 bulk selection was used to select cells stably overexpressing the GD3 synthase.An aminoglycoside antibiotic, G418, has been shown to be an inhibitor of many pro- and eukaryotes at concentrations from 1-300 microgram/ml.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, stored under nitrogen, away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)；

结构分类

Antibiotics
Other

来源

Micromonospora rhodorangea

溶解度数据	体外研究: H₂O : 125 mg/mL(180.45 mM;Need ultrasonic) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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