Vancomycin|1404-90-6|(万古霉素)-陌孚医药/Medlife

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Vancomycin (Synonyms: 万古霉素)

目录号: PC61262 纯度: ≥96%

CAS No. :1404-90-6

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中文名称	Vancomycin
中文别名	万古霉素;凡古霉素;凡可霉素;盐酸万古霉素
英文名称	Vancomycin
英文别名	Vancomycin;Vancomycin HCl;22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine,vancomycin deriv.;Vancocin;Vancoled;Vancomycinum;Vancomycine;Vancomicina;Vancomycinum [INN-Latin];Vancomycine [INN-French];VANCOR;Vancomicina [INN-Spanish];6Q205EH1VU;Vancocin HCL;Vancomycin (USP);vancomicin;vanomycin;Vancomycin [USP:INN:BAN];Vancomycin [USAN:INN:BAN];Vancomycin hydrochloride from Streptomyces orientalis;C66H75Cl2N9O24;Viomycin derivative;[(2S,3R,4S,5S,6R)-3-[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6
Cas No.	1404-90-6
分子式	C₆₆H₇₅Cl₂N₉O₂₄
分子量	1449.25
包装储存	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性	Vancomycin is an antibiotic for the treatment of bacterial infections.
性状	Solid
IC50 & Target[1][2]	Glycopeptide

体外研究(In Vitro)

Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da. Vancomycin is a unique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects. Vancomycin treatment of infected mice is associated with improved clinical, diarrhea, and histopathology scores and survival during treatment.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

ClinicalTrial

结构分类

Antibiotics
Other

来源

Streptomyces orientalis.

溶解度数据	体外研究: DMSO : 125 mg/mL(86.25 mM;ultrasonic and warming and heat to 60°C) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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