Ouabain Octahydrate|11018-89-6|(Acocantherine; G-Strophanthin)-陌孚医药/Medlife

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Ouabain Octahydrate (Synonyms: Acocantherine; G-Strophanthin)

目录号: PC66795 纯度: ≥99%

CAS No. :11018-89-6

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中文名称	Ouabain Octahydrate
中文别名	毒毛旋花苷;十水合乌本苷;2-氧杂-6-氮杂-螺[3,3]庚烷-6-甲酸叔丁酯;4-(2-噻酚基)苯基硼酸;g-Strophanthin Octahydrate g-羊角拗质;g-羊角拗质;毒毛旋花苷G;环已酮;乌本( 箭毒) 苷, 哇巴因;乌本苷;G毒毛旋花苷;哇巴因;乌巴因;乌本(箭毒)苷;羊角拗质;乌本苷八水合物;毒毛旋花苷G (羊角拗质、乌本( 箭毒) 苷、哇巴因、乌本苷、G毒毛旋花苷、乌本苷八水合物);G毒毛旋花苷/乌本苷
英文名称	Ouabain Octahydrate
英文别名	Card-20(22)-enolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-,hydrate (1:8), (1b,3b,5b,11a)-;Ouabain octahydrate;Card-20(22)-enolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-,hydrate (1:...;OUABAIN OCTAHYDRATE,HPLC;Strophantine Octahydrate;Acocantherine;G-Strophanthin;g-Strophanthin Octahydrate;1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside);(1beta,3beta,5beta,11alpha)-3-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-card-20(22)-enolide octahydrate;OUABAIN 8H2O;OUABAIN 8H20;G-Strophantin;STROPHANTHIN G;OUABAIN HYDRATE;OUBAIN OCTAHYDRATE;(-)-OUABAIN OCTAHYDRATE;Ouabain octahydrate,96%;Ouabain octahydrate 96%;ouabain;Ouabaine;Oubain;Ouabagenin L-rhamnoside;Ouabain anhydrous;Uabanin;Ouabagenin-L-rhamnosid;Purostrophan;Strodival;Gratibain;Astrobain;Acocantherin;Strophanthin-G;Strophalen;Uabaina;Kombetin;Gratus strophanthin;Strophoperm;Strophosan;Solufantina;Rectobaina;G-Strophicor;Quabain;MLS000069786;LPMXVESGRSUGHW-HBYQJFLCSA-N;Ouabain, Octahydrate;5ACL011P69;Ouabagenin-L-rhamnosid [German];SMR000058492
Cas No.	11018-89-6
分子式	C₂₉H₄₄O₁₂
分子量	584.65
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Ouabain Octahydrate is an inhibitor of Na/K-ATPase, used for the treatment of congestive heart failure.
性状	Solid
体外研究(In Vitro)	Ouabain (100 μM) induces NLRP3 inflammasome activation and IL-1β release in macrophages. Ouabain-induced NLRP3 inflammasome activation is mediated through K efflux. Ouabain (3 nM) alters the expression of EMT markers in NHK and ADPKD cells, and modifies cell-cell adhesion properties in ADPKD. Moreover, ouabain enhances migration of ADPKD cells, selectively modulates tight junctions, and modulates adherens junctions in ADPKD cells in a selective manner. Ouabain also activates TGFβ-Smad3 signaling, alters TER in ADPKD cells. Ouabain (25, 50 or 100 nM) treatment significantly reduces cell proliferation and viability in Raji cells in a dose-dependent manner, with IC50 of 76.48±4.03 nM. Ouabain increases the number of apoptotic cells, induces autophagy, and upregulates Beclin-1 in Raji cells.Medlife has not independently
体内研究(In Vivo)	Ouabain (3 mg/kg) significantly decreases cardiac contractile force with an enlarged LVESD when mice are primed with LPS. IL-1β deficiency attenuates ouabain-induced cardiac dysfunction and injury. IL-1β secreted by infiltrated macrophages contributes to ouabain-induced cardiac inflammation. Deficiency of NLRP3 and Casp1 attenuates ouabain-induced cardiac dysfunction and macrophage infiltration. Ouabain (30 μg/kg, i.p.) modulates ABCB1 activity in thymocytes of Wistar rats and it has the same effect on Swiss mice at 300 μg/kg. After 14 days of ouabain treatment, the MAP of rats is significantly elevated.Medlife has not independently confirmed the accuracy of these methods. They are for reference only. <
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Steroids

溶解度数据	体外研究: DMSO : ≥ 125 mg/mL(171.52 mM) H₂O : 10 mg/mL(13.72 mM;ultrasonic and warming and heat to 60°C) *≥ means soluble, but saturation unknown.

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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