Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active.

Solid

Microbial Metabolite
 Human Endogenous Metabolite
 

Ursodeoxycholic acid (50, 150, and 450 mg/kg; p.o.; daily for 21 days) sodium results in weight loss in C57BL/6J wildtype mice.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:5 week

Room temperature or refrigerated transport.

4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

Steroids

intestinal bacteria

体外研究:
DMSO : 125 mg/mL(301.53 mM;ultrasonic and warming and heat to 60°C)
H₂O : ≥ 100 mg/mL(241.23 mM)
*≥ means soluble, but saturation unknown.