Triptolide.|38748-32-2|(雷公藤甲素; PG490)-陌孚医药/Medlife

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Triptolide. (Synonyms: 雷公藤甲素; PG490)

目录号: PC64053 纯度: ≥99%

CAS No. :38748-32-2

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中文名称	Triptolide.
中文别名	雷公藤甲素;雷公藤多甙;雷藤素甲;雷公藤内酯醇;雷公藤甲素(雷公藤内酯醇) TLC;雷公藤甲素(雷公藤内酯醇);2-甲基-1 8-萘啶-3-羧酸;Triptolide 雷公藤甲素;Triptolide 雷公藤甲素标准品;zzstandard 品牌雷公藤甲素对照品;雷公藤甲素对照品标准品;雷公藤甲素 Triptolide;雷公藤甲素雷公藤内酯醇雷公藤多甙 Triptolide;雷公藤甲素(P);雷公藤甲素（标准品）;雷公藤甲素（雷公藤内酯醇）,Triptolide,植物提取物,标准品,对照品;雷公藤甲素,分析标准品;雷公藤甲素粉末;雷公藤甲素固体状;雷公藤甲素中间体;雷公藤提取物;雷公藤提取物（雷公藤甲素）;临床实验雷公藤甲素;藤甲素;医药级雷公藤甲素;雷公藤甲素(雷公藤多甙,雷公藤内酯醇,雷藤素甲);雷公藤甲素,雷公藤内酯醇;雷公藤内酯醇,雷公藤多甙
英文名称	Triptolide
英文别名	triptolide;PG490;TRIPTOLIDE, TRIPTERYGIUM WILFORDII;8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-,(3bs,4as,5as,6r,6ar;TRIPTOLIDE TLC;TRIPTOLIDE(P);TRIPTONIDE(P);(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one;NSC 163062;TRIPTOLIDE(P) PrintBack;Triptolide(PG490);Triptolide(TPL,PG490,NSC 163062);Triptonide;Common Threewingnut Root Extract;(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-6a-isopropyl-8b-methyltrisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1(3H)-one;(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one;PG-490;triptergium wilfordii;TRIPTO;triptolid;Triptolide?;(-)-Triptolide;[3bS-(3ba,4aa,5aR,6b,6ab,7ab,7ba,8aR,8bb)]-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one;PG 490;19ALD1S53J;C20H24O6;Triptolide (PG490);CPD000466307;SMR000466307;NSC163062;Triptolide, 1;Triptolide(PG490)/;BSPBio_001595;KBioSS_000315;KBioGR_000315;MLS006010844;MLS001424107
Cas No.	38748-32-2
分子式	C₂₀H₂₄O₆
分子量	360.40
包装储存	4°C, stored under nitrogen；*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)；

生物活性

Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor.

性状

Solid

IC50 & Target[1][2]

HSP90
MDM-2/p53
47-73 nM (IC50)

体外研究(In Vitro)

Triptolide induces apoptosis in cultured and primary Chronic Lymphocytic Leukemia (CLL) B-cells. Treatment of CD19 B cells with Triptolide, induces a dose-dependent increase in apoptosis in cultured and primary CLL cells. Triptolide is selectively toxic to both high risk (n=5) and low risk CLL (n=12) B cells (10 to 50 nM range) while largely sparing normal B-cells (n=5). Consistent with the inhibition of heat-shock induced HSP transcription, treatment with Triptolide attenuates heat-shock induced expression of HSPs. Triptolide is a natural product derived from the Chinese plant Tripterygium wilfordii, is reported to exhibit antitumor effects in a broad range of cancers. Triptolide inhibits MDM2 expression in a dose-dependent manner, even at low concentrations spanning 20-100 nM in acute lymphoblastic leukemia (ALL) cells. Triptolide exhibits strongly cytotoxic activity

体内研究(In Vivo)

The Triptolide (TP) plasma concentrations are declined rapidly in mice after receive an intravenous dose. After 2h of injection, the Triptolide concentrations are dropped below the lower limit of quantification for all three groups. A comparison of the parameters is made between the control and the treated groups to assess the effect of P-gp inhibition on the Triptolide exposure and elimination. Treatment with the mdr1a-siRNA can significantly enhance the Triptolide plasma exposure, with the Cmax increases from 413±74 to 510±94 ng/mL (P<0.05) and the AUC from 103.5±9.6 to 154.3±30.2 ng?h/mL (P<0.05). In the concomitant group with Tariquidar, the significantly increased AUC is also noted, from 103.5±9.6 of the control to 145.9±24.6 ng?h/mL of the Triptolide+Tariquidar group (P<0.05). Accordingly, the total body clearance of Triptolide in mice is remarkably d

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, stored under nitrogen；*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)；

ClinicalTrial

结构分类

Terpenoids
Diterp

来源

Plants

溶解度数据	体外研究: DMSO : 25 mg/mL(69.37 mM;Need ultrasonic) H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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