Baicalin.|21967-41-9|(黄芩苷; Baicalein 7-O-β-D-glucuronide)-陌孚医药/Medlife

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Baicalin. (Synonyms: 黄芩苷; Baicalein 7-O-β-D-glucuronide)

目录号: PC60254 纯度: ≥99%

CAS No. :21967-41-9

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中文名称	Baicalin.
中文别名	黄芩苷;贝加灵;黄芩甙;黄芩素;黄芩苷BAICALIN;(7-黄芩苷)-Β-D-葡萄糖苷酸;1-[(5-乙基-2-噻吩)甲基]哌嗪;穿琥宁;葛根提取物;黄岑提取物;黄芩甙标准品(JP);黄芩苷 EP标准品;黄芩苷(P);黄芩苷植物提取物,标准品,对照品;黄芩苷对照品;黄芩苷粉;黄芩提取物;柠檬粉;黄岑甙;黄苓甙;黄芩苷标准品;黄芩素-7-O-β-D-葡萄糖醛酸苷;秦皮甲素;秦皮素;秦皮乙素;野黄芩苷;5,6-二羟基-4-氧代-2-苯基-4H-1-苯并吡喃-7-基-D-葡糖苷酸;哈密瓜提取物;中药黄芩提取物
英文名称	Baicalin
英文别名	Baicalin;BAICALEIN 7-BETA-D-GLUCOPYRANOSIDURONATE HYDRATE;BAICALIN 7-BETA-D-GLUCOPYRANOSIDURONATE HYDRATE;BAICALIN HYDRATE;Baicalin Injection;Bassora;Radix;ASTRAGALIN(KAEMPFEROL-3-O-GLUCOSIDE)(P);BAICALIN(P);7-GLUCURONICACID-5,6-DIHYDROXYFLAVONE;BAICALIN WITH HPLC;BAICALIN hplc;5,6-Dihydroxy-4-oxygen-2-phenyl-4H-1-benzopyran-7-beta-D-glucopyranose acid;Baicalein 7-O-glucuronide;BAICALINB-D-GLUCOPYRANOSIDURONIC ACID, 5,6-DIHYDROXY-4-OXO-2-PHENYL-4H-1-BENZOPYRAN-7-YL;BAICALIN 7-B-D-GLUCOPYRANOSIDURONATE HYDRATE;5,6-Dihydroxy-7-(β-D-glucopyranuronosyloxy)flavone;5,6-Dihydroxyflavon-7-yl β-D-glucopyranosiduronic acid;Baicalein 7-O-β-D-glucuronide;BAICALIN(AS);BAICALIN(P) PrintBack;5,6-Dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl β-D-Glucopyranosiduronic Acid;Baicailin;Baicaloside;WAKO024-15691;5,6-Dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl-β-D-glucopyranosiduronic acid;[ "" ];Cantaloupe extract.;Scutellana baicalensis Georgi;7-D-Glucuronic acid-5,6-dihydroxyflavone;Baicalein 7-O-;A-D-glucuronide;5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid;347Q89U4M5;(2S,3S,4S,5R,6S)-6-((5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid;5,6,7-trihydroxyflavone 7-O-beta-D-glucuronide;beta-D-Glucopyranosiduronic acid, 5,6-dihydroxy-4-o
Cas No.	21967-41-9
分子式	C₂₁H₁₈O₁₁
分子量	446.36
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of NF-κB.
性状	Solid
IC50 & Target[1][2]	NF-κB Autophagy
体外研究(In Vitro)	Baicalin protects against ischemia-reperfusion injury (IRI) by altering the production of various mediators, including reactive oxygen species (ROS), Toll-like receptor (TLR)2 and TLR4, NF-κB, Bax, and Bcl-2. Baicalin treatment inhibits the increased expression of the proinflammatory cytokines TLR2/4, MyD88, p-NF-κB, and p- IκB, as well as increase the expression of IκB protein, an NF-κB inhibitor, with the degree of inhibition positively related to the dosage of Baicalin. Cell viability is determined by MTT assay. Compared with control cells, cell viability is significantly decreased in SH-SY5Y cells treated with thrombin. Pre-treatment with Baicalin(5, 10, 20 μM) increases cell viability in a dose-dependent manner compared with cells treated thrombin alone.Medlife has not independently confirmed the accuracy of these metho
体内研究(In Vivo)	Baicalin pretreatment dose-dependently protects against a loss of renal function, with the two higher doses (10 and 100 mg/kg) significantly decreasing Scr and blood urea nitrogen (BUN) concentrations. Tissue injury, as assessed using a 0-3 point scoring system, is lower for the Baicalin treated groups than for the ischemia-reperfusion (IR)+saline group. Compared with the sham group, malondialdehyde (MDA) content is only slightly up-regulated and the SOD activity is only slightly down-regulated in rats treated with 10 and 100 mg/kg Baicalin, indicating that Baicalin abrogates the increase in oxidative stress following reperfusion.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Flavonoids Flavon
来源	Plants

溶解度数据	体外研究: DMSO : ≥ 100 mg/mL(224.03 mM) H₂O : 0.1 mg/mL(0.22 mM;Need ultrasonic) *≥ means soluble, but saturation unknown.

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