1-Deoxynojirimycin hydrochloride|73285-50-4|(Duvoglustat hydrochloride)-陌孚医药/Medlife

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1-Deoxynojirimycin hydrochloride (Synonyms: Duvoglustat hydrochloride)

目录号: PC63961 纯度: ≥96.0%

CAS No. :73285-50-4

商品编号	规格	价格	会员价	是否有货	数量
PC63961-1mg	1mg	询价	询价
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中文名称	1-Deoxynojirimycin hydrochloride
中文别名	去氧野艽霉素盐酸盐;1-脱氧野尻霉素;1-脱氧野尻霉素盐酸盐;O-去甲基吉非替尼
英文名称	1-Deoxynojirimycin hydrochloride
英文别名	Deoxynojirimycin hydrochloride;(+)-1-Deoxynojirimycin hydrochloride;1-Deoxynojirimycin (hydrochloride);DEOXYNOJIRIMYCIN;(+)-(2R,3R,4R,5S)-2-hydroxymethyl-3,4,5-trihydroxypiperidine hydrochloride;(+-)-1-Chlor-8,9-dihydro-inden;(1R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidinium chloride;1,5-dideoxy-1,5-imino-D-glucitol hydrochloride;1H-Indene,1-chloro-3a,7a-dihydro;1-Deoxynojirimycin hydrochloride
Cas No.	73285-50-4
分子式	C₆H₁₃NO₄^.HCl
分子量	199.63
包装储存	4°C, Sealed and stored away from moisture and light；*In solvent : -80°C, 6 months; -20°C, 1 month (Sealed and stored away from moisture and light)；

生物活性

1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features.

性状

Solid

体内研究(In Vivo)

1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) (20-80 mg/kg; i.v.; daily for four weeks) shows anti-obesity effect .
1-Deoxynojirimycin hydrochloride significantly improves insulin sensitivity via activating insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, Sealed and stored away from moisture and light；*In solvent : -80°C, 6 months; -20°C, 1 month (Sealed and stored away from moisture and light)；

ClinicalTrial

结构分类

Saccharides
Monos

来源

Plants

参考文献

[1]. Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21(11). pii: E1600.
[2]. Chaluntorn Vichasilp,et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232.

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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