Ascomycin|104987-12-4|(子囊霉素; Immunomycin; FR-900520; FK520)-陌孚医药/Medlife

您当前的位置：

Ascomycin (Synonyms: 子囊霉素; Immunomycin; FR-900520; FK520)

目录号: PC61288 纯度: ≥98.0%

CAS No. :104987-12-4

商品编号	规格	价格	会员价
PC61288-5mg	5mg	¥427.50	请登录
PC61288-10mg	10mg	¥522.50	请登录
PC61288-1mL	1mL	¥475.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Ascomycin
中文别名	长川霉素;子囊霉素;Ascomycin 抑制剂;四水合铬酸钠;子囊;子囊霉素标准品;8-乙基-3-（2-（4-羟基-3-甲氧环己基）-1-甲基乙烯基）-14,16-二甲烷;长川霉素子囊霉素
英文名称	Ascomycin
英文别名	Ascomycin;AAG;FK-520;FR-900520;IMMUNOMYCIN;ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS;ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS VAR ASCOMYCETICUS;12,18-tetramethyl-,(3s-(3r(e(1s,3s,4s)),4s,19s,26ar))--10;8-ethyl-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy;Ascomycin (FK 520,Immunomycin, FR-900520, L 683590,Changchuanmycin);Ascomycin solution; 1,4-dideoxy-(1S)-1-C-(4-hydroxypyrrolo[3,2-d]pyrimidin-7-yl)-1,4;4H-Pyrrolo3,2-dpyrimidin-4-one,7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro;7-((2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one;7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one;changchuanmycin;FK 520;Fodosine;FR 900520;Isopamphos;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-,[3S-[3R[E(1S,3S,4S)],4S,5R,8S,9E,12R,14R,15S,16R,18S,19S,26aR*]]-;FR 520;L 683590;FK520;Ascomycin (FK520);AUF4U5NSJK;Ascomycin(FK 520);C43H69NO12
Cas No.	104987-12-4
分子式	C₄₃H₆₉NO₁₂
分子量	792.01
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research.
性状	Solid
IC50 & Target[1][2]	Plasmodium

体外研究(In Vitro)

Ascomycin (FR-900520) suppresses immune response in vitro with an IC50 value of 0.55 nM for mouse mixed lymphocyte reaction.
Ascomycin is a powerful calcium-dependent serine/threonine protein phosphatase (calcineurin [CaN], protein phosphatase 2B) inhibitors. Its mechanism of action involves the formation of a molecular complex with the intracellular FK506-binding protein-12 (FKBP12), thereby acquiring the ability to interact with CaN and to interfere with the dephosphorylation of various substrates.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Ascomycin (FR-900520; i.m.; 0.32-32 mg/kg; 5 days a week; for 2 weeks) clearly prolongs skin allograft survival in rats.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:WKA rats (8-10

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

结构分类

Antibiotics
Macro

来源

Streptomyces tubercidicus

溶解度数据	体外研究: DMSO : ≥ 39 mg/mL(49.24 mM) *≥ means soluble, but saturation unknown. 配制储存液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation