Songorine|509-24-0|(宋果灵)-陌孚医药/Medlife

您当前的位置：

Songorine (Synonyms: 宋果灵)

目录号: PC63083 纯度: ≥99%

CAS No. :509-24-0

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Songorine
中文别名	桑果林;准葛尔乌头碱;雪上一枝蒿 G;一枝蒿素 B;宋果灵;华北;雪上一枝蒿素 G;一枝蒿庚素;宋果灵对照品;松果灵;一枝蒿庚素对照品;准噶尔乌头碱;华北乌头碱;雪上一支蒿素G;雪上一枝蒿庚素;一枝蒿庚素（标准品）;准格尔乌头碱
英文名称	Songorine
英文别名	(20R)-21-Ethyl-1α,15β-dihydroxy-4-methyl-16-methylene-7α,20-cycloveatchan-12-one;Napellonine;Zongorine;(3R,6S,6aR,6bR,9R,11R,11aR,12R,12aR,14R)-1-Ethyldodecahydro-6,11-dihydroxy-3-methyl-10-methylene-12,3,6a-ethanylylidene-9,11a-methanoazuleno[2,1-b]azocin-8(9H)-one;Napellonin;Xuan-Wu 2;Bullatine G;Songorin;Songorine;[ "" ];Bullatine;Oprea1_838993;STL372872;BBL034030
Cas No.	509-24-0
分子式	C₂₂H₃₁NO₃
分子量	357.49
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性	Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer,antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC).
性状	Solid
IC50 & Target[1][2]	IC50: GABAA receptor
体内研究(In Vivo)	Songorine is investigated itsefficacy and safety in SKOV3 tumorbearing BALB/c nude mice, songorine inhibits EOC cell survival, invasion and migration, promoted EOC cell apoptosis and suppressed mammalian EOC tumorigenic behavior. In addition, western blot and IHC results show that songorine consistently downregulates the expression of Ncadherin, vimentin, matrix metalloproteinase (MMP)2, MMP9, phosphorylated GSK3β, βcatenin and Bcl2, and upregulated the expression of Ecadherin, cleaved caspase3, cleaved caspase9 and Bax. Songorine shows an Antiarrhythmic activity in aconitine-induced arrhythmia model in rats, exhibits LD50 and ED50 values of 142 mg and 7.3mg, respectively. Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；
结构分类	Alkaloids Other A
来源	Plants

溶解度数据	体外研究: DMSO : 100 mg/mL(279.73 mM;Need ultrasonic) 配制储存液

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品