Ginsenoside Rb1|41753-43-9|(人参皂苷 Rb1; Gypenoside III)-陌孚医药/Medlife

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Ginsenoside Rb1 (Synonyms: 人参皂苷 Rb1; Gypenoside III)

目录号: PC64049 纯度: ≥98%

CAS No. :41753-43-9

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中文名称	Ginsenoside Rb1
中文别名	人参皂苷 Rb1;人参皂甙 Rb1;WAKO079-02191人参皂苷Rb1标准品;八氯苯乙烯;人参皂苷 Rb1 Ginsenoside Rb1;人参皂苷 Rb1 橙皮苷新橙皮苷盐酸巴马汀;人参皂苷 Rb1(AS);人参皂苷 Rb1标准品(JP);人参皂苷Rb 3;人参皂苷Rb1 对照品标准品;人参皂苷Rb1 EP标准品;人参皂苷Rb1 标准品;人参皂苷Rb1(标准品);人参皂苷Rb1(三七皂苷Rb1);人参皂苷Rb1,Ginsenoside-Rb1,植物提取物,标准品,对照品;人参皂苷Rg1纯度标准物质;分析对照品;人参皂甙;人参皂苷Rg1纯度标准物质人参皂甙 Rb1;人参皂苷Rb1
英文名称	Ginsenoside Rb1
英文别名	ginsenoside rb1;GINSENOSIDE GINSENOSIDE-RB1;Ginsenoside Rb1 (saponin of panax ginseng);GINSENOSIDE Rb1(P) PrintBack;Ginsenoside-Rb1;ginsinoside Rb1;Gypenoside III;Ginsenoside Rb1;arasaponine1;ginseng Rb1;Ginsenoside-Rb1 from Panax ginseng (Korean ginseng) root;gynosaponinc;GYPENOSIDE;Gypenoside I;Panaxoside Rb1;panaxsaponine;SANCHINOSIDE E1;2-O-β-Glucopyranosyl-(3β,12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl β-D-glucopyranoside;(3beta,12beta)-20-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside;(3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2S,3S,4R,5R,6S)-4,5-D;(3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2S,3S,4R,5R,6S)-4,5-Dihydroxy-6-(hydroxymethyl)-3-[(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol;CID 117590645;2-[[6-[(2S)-2-[(8R,10R,14R)-3-[4,5-dihydroxy-6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)
Cas No.	41753-43-9
分子式	C₅₄H₉₂O₂₃
分子量	1109.30
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na, K-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .
性状	Solid
IC50 & Target[1][2]	Na, K-ATPase 6.3 μM (IC50)IRAK-1
体外研究(In Vitro)	Rat brain microsomal Na, K-ATPase activity is inhibited significantly and rapidly by Ginsenoside Rb1. The IC50 of Ginsenoside Rb1 for Na,K-ATPase is 6.3±1.0 μM. The inhibition is enhanced with increasing the concentration of Ginsenoside Rb1 or decreasing that of Na and K. Kinetic analysis reveals that Ginsenoside is an uncompetitive inhibitor with respect to ATP.Ginsenoside Rb1 significantly inhibits the activation of interleukin-1 receptor-associated kinase-1 (IRAK-1), IKK-β, NF-κB, and MAP kinases (ERK, JNK, and p-38); however, interaction between LPS and Toll-like receptor-4, IRAK-4 activation and IRAK-2 activation are unaffected. Ginsenoside Rb1 is an ingredient of a Chinese medicine Panax ginseng. Ginsenoside Rb1 is a major bioactive compound in the regulating pregnane X receptor (PXR)/NF-κB signaling. Ginsenoside Rb1 is the compound with potent anti
体内研究(In Vivo)	Ginsenoside Rb1 at the both doses of 30?mg/kg and 60?mg/kg significantly attenuates the histological lung injury. Ginsenoside Rb1 at the dose of 30?mg/kg and 60?mg/kg both significantly attenuates the histological intestine injury. Ginsenoside Rb1 (Rb1), an ingredient of a Chinese medicine Panax ginseng, has beneficial effects on mesentery microvascular hyperpermeability induced by Lipopolysaccharide (LPS) and the underlying mechanisms. In some rats, Ginsenoside Rb1 (5 mg/kg per hour) is administrated through the left jugular vein 30 min after LPS infusion. Ginsenoside Rb1 decreases caveolae number in endothelial cells of microvessels. Ginsenoside Rb1 ameliorates microvascular hyperpermeability after the onset of endotoxemia and improves intestinal edema through inhibiting caveolae formation and junction disruption, which is correlated to suppression of NF-κB and Src ac
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Terpenoids Triter
来源	Plants

溶解度数据	体外研究: DMSO : 100 mg/mL(90.15 mM;Need ultrasonic) H₂O : ≥ 33.33 mg/mL(30.05 mM) *≥ means soluble, but saturation unknown.

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