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Brefeldin A (Synonyms: 布雷非德菌素 A; BFA; Cyanein; Decumbin)

目录号: PC61239 纯度: ≥99%

CAS No. :20350-15-6

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中文名称	Brefeldin A
中文别名	布雷非德菌素 A;布雷菲德菌素 A;Brefeldin A 抑制剂;布雷非德菌素 A Brevetoxin A;布雷非德菌素A, 来源于土壤霉菌;布雷菲德菌素A,Brefeldin A ,植物提取物,标准品,对照品;布雷菲德菌素A,蓝菌素 A;布雷菲尔得菌素A;γ,4-二羟基-2-(6-羟基-1-庚烯基)-4-环戊烷巴豆酸-λ-内酯;壳二孢毒素;蓝菌素
英文名称	Brefeldin A
英文别名	Brefeldin A;1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent [f]oxacyclotridecin-4-one;Ascotoxin;Cyanein;BFA;Brefeldin;Brefeldin A (BFA,NSC 89671,Decumbin, Ascotoxin, Cyanein, Nectrolide, Synergisidin);Brefeldin A, natural;cyanaein;DECUMBIN;NECTROLIDE;Synergisidin;γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic Acid λ-Lactone;(1S,3Z,7R,11E,13R,15R)-2,15-Dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-one
Cas No.	20350-15-6
分子式	C₁₆H₂₄O₄
分子量	280.36
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A is a CRISPR/Cas9 activator. Brefeldin A inhibits HSV-1 and has anti-cancer activity.
性状	Solid
IC50 & Target[1][2]	CRISPR/Cas9 HSV-1
体外研究(In Vitro)	Brefeldin A (BFA) treatment for 15 h or 40 h, causes dramatic swelling of the Endoplasmic Reticulum (ER) and shifts its localization to the periphery of normal rat kidney (NRK) cells. Prolonged Brefeldin A treatment results in marked disruption of the MT and actin cytoskeleton. ADP-ribosylation of BARS is mediated by formation of a conjugate between Brefeldin A and ADPR. BARS shows BAC binding when incubated with the medium from the BFA-treated CD38 HeLa cells. Brefeldin A induces anchorage-independent cell death in MDA-MB-231 breast cancer cells, inhibits the formation of MDA-MB-231 colonies in 3D and 2D cultures and inhibits the migration and MMP 9 (Matrix Metallopeptidase 9) activity of MDA-MB-231.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Antibiotics Macro
来源	Penicillium

溶解度数据	体外研究: DMSO : 100 mg/mL(356.68 mM;Need ultrasonic) Ethanol : 11.11 mg/mL(39.63 mM;Need ultrasonic) 配制储存液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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