Lycorine hydrochloride.|2188-68-3|(石蒜碱)-陌孚医药/Medlife

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Lycorine hydrochloride. (Synonyms: 石蒜碱)

目录号: PC62886 纯度: ≥98%

CAS No. :2188-68-3

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中文名称	Lycorine hydrochloride.
中文别名	盐酸石蒜碱;6-碘苯并二氢吡喃-4-醇;Lycorine chloride 盐酸石蒜碱标准品;石蒜碱;盐酸石蒜碱（标准品）;盐酸石蒜碱,Lycorine Hydrochloride,植物提取物,标准品,对照品;盐酸石蒜碱\石蒜碱盐酸盐、水仙碱、异鼠李素-3-Β-D-芸香糖甙;盐酸石蒜碱Lycorine chloride;葫芦巴碱盐酸盐;石蕊碱;盐酸葫芦巴碱;盐酸石蒜碱(石蒜碱盐酸盐,水仙碱);盐酸石蒜碱,Lycorine chloride,分析标准品;盐酸石蒜碱,Lycorine hydrochloride,对照品,标准品,中草药;盐酸石蒜碱，医药级,纯度:>99%
英文名称	Lycorine hydrochloride
英文别名	Lycorine hydrochloride;Lycorine chloride;Lycorine (hydrochloride);Lycorine Hydrochlori;galanthidine,hydrochloride;Licorin hydrochloride;(1R,17S,18R,19S)-5,7-Dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-1;A905098;(1S,2S,12BS,12CS)-1,2,4,5,12B,12C-Hexahydro-7H-[1,3]dioxolo[4,5-J]pyrrolo[3,2,1-DE]phenanthridine-1,
Cas No.	2188-68-3
分子式	C₁₆H₁₇NO₄
分子量	287.31
包装储存	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性	Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. andis also a melanoma vasculogenic inhibitor and has anti-tumor activity. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC₅₀ of 1.2 μM).
性状	Solid
IC50 & Target[1][2]	IC50: 1.2 μM (Hey1B cells )
体外研究(In Vitro)	Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected. Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.Medlife has not independently confirmed the accuracy of these methods. They are for reference only. ass="cpd-vitro
体内研究(In Vivo)	Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.Medlife has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature or refrigerated transport.
储存方式	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；
结构分类	Alkaloids Isoquin
来源	Plants

溶解度数据	体外研究: DMSO : 25 mg/mL(77.22 mM;Need ultrasonic) H₂O : 16.67 mg/mL(51.49 mM;Need ultrasonic) 配制储存液

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