Pregnenolone.|145-13-1|(孕烯醇酮; 3β-Hydroxy-5-pregnen-20-one)-陌孚医药/Medlife

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Pregnenolone. (Synonyms: 孕烯醇酮; 3β-Hydroxy-5-pregnen-20-one)

目录号: PC66840 纯度: ≥99%

CAS No. :145-13-1

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中文名称	Pregnenolone.
中文别名	妊娠烯醇酮;3-羟基-5-妊烯酮;5-孕甾烯-3β-醇-20-酮;3β-羟基孕甾-5-烯-20-酮;苯酮;妊烯醇酮;孕烯醇酮;孕甾烯醇酮;1-羟基环己基甲酸;Pregnenolone 孕烯醇酮;Pregnenolone 孕甾烯醇酮标准品;妊娠烯醇酮,Pregnenolone;妊娠烯醇酮,孕烯醇酮;妊娠烯醇酮、孕烯醇酮;孕烯醇酮标准品;孕烯雌酮;孕烯醇酮.孕烯醇酮醋酸酯;孕烯醇酮/妊烯醇酮
英文名称	Pregnenolone
英文别名	Pregnenolone;DELTA5-PREGNEN-3BETA-OL-20-ONE;DELTA5-PREGNEN-3B-OL-20-ONE;DELTA-5-PREGNENE-3B-OL-20-ONE;DELTA5-PREGNENOLONE;1-((3S,8S,9S,10R,13S,14S,17S)-3-HYDROXY-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL)-ETHANONE;3BETA-HYDROXY-5-PREGNEN-20-ONE;3BETA-HYDROXYPREGN-5-EN-20-ONE;3b-hydroxy-5-pregnen-20-one;5-Pregnen-3β-ol-20-one;PREGNENOLONE(P);3β-Hydroxy-5-pregnen-20-one;3β-Hydroxypregn-5-en-20-one;Arthenolone;Pregnelone;Pregnenlolone;pregnolon;prenenolone;prenolon;Progeserone;ZK-5553;5-Pregnenolone;3-Hydroxypregn-5-en-20-one;[ "3-Hydroxypregn-5-en-20-one" ];Pregnenolone 0;Regnosone;Pregnetan;Skinostelon;Pregneton;Enelone;Natolone;Bina-Skin;Pregnenolone [INN:BAN];Pregnenolonum [INN-Latin];Pregnenolona [INN-Spanish];Prestwick_859;Prestwick3_000546
Cas No.	145-13-1
分子式	C₂₁H₃₂O₂
分子量	316.48
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

性状

Solid

IC50 & Target[1][2]

CB1
Human Endogenous Metabolite

体外研究(In Vitro)

CB1 receptor stimulation increases brain Pregnenolone levels, which in turn exerts a negative feedback on the activity of the CB1 receptor antagonizing most of the known behavioral and somatic effects of THC. Pregnenolone likely acts as a signaling-specific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands. Pregnenolone does not modify agonist binding but only agonist efficacy.
The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC).Medlife has not independently confirmed

体内研究(In Vivo)

Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Steroids

溶解度数据	体外研究: DMSO : 25 mg/mL(78.99 mM;ultrasonic and warming and heat to 60°C) H₂O : 0.1 mg/mL(0.32 mM;Need ultrasonic) 配制储存液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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