4°C, Keep In Dark;*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark);
生物活性
L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells.
性状
Solid
IC50 & Target[1][2]
Microbial Metabolite Human Endogenous Metabolite
体外研究(In Vitro)
The anti-cancer effects of L-Ascorbic acid are determined by sodium-dependent vitamin C transporter 2 (SVCT-2), a transporter of L-ascorbic acid. L-Ascorbic acid (0.1 μM-2 mM) exhibits anti-cancer effects according to SVCT-2 expression and L-ascorbic acid uptake. Human colorectal cancer cell lines displays differential responses to L-ascorbic acid, primarily depending on the expression level of SVCT-2.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.ass="cpd-vitro-list">
体内研究(In Vivo)
L-Ascorbic acid/Tolbutamide produces hypoglycaemic activity in a dose dependant manner in normal (60 mg/kg) and diabetic (40 mg/kg) condition. In the presence of L-ascorbic acid, Tolbuatmide (20 mg/kg) produces early onset of action and maintained for longer period compared to Tolbutamide matching control.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature or refrigerated transport.
储存方式
4°C, Keep In Dark;*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark);
ClinicalTrial
结构分类
Others
来源
Plants
溶解度数据
体外研究:DMSO : 100 mg/mL(567.79 mM;Need ultrasonic)H2O : ≥ 100 mg/mL(567.79 mM)*≥ means soluble, but saturation unknown.