Kaempferitrin|482-38-2|(山奈苷; Lespedin; Lespenephryl)-陌孚医药/Medlife

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Kaempferitrin (Synonyms: 山奈苷; Lespedin; Lespenephryl)

目录号: PC58851 纯度: ≥99%

CAS No. :482-38-2

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中文名称	Kaempferitrin
中文别名	山奈苷;Kaempferitrin 山奈苷标准品;山奈苷(山奈酚-3,7-二鼠李糖苷);山奈苷,KAEMPFEROL-3,7-DIRHAMNOSIDE,植物提取物,标准品,对照品;山奈苷标准品;山柰苷;山奈酚-3,7-O-L-二鼠李糖苷;山奈酚-3,7-二鼠李糖苷;山奈苷,Kaempferitrin;山柰酚-3,7-二-O-鼠李糖苷
英文名称	Kaempferitrin
英文别名	KAEMPFERITRIN;4H-1-Benzopyran-4-one,3,7-bis[(6-deoxy-a-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-;5-hydroxy-2-(4-hydroxyphenyl)-3,7-bis[[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy]chromen-4-one;C27H30O14;KAEMPFERITRIN(P);Kaempferol 3,7-L-dirhamnoside;kaempferol 3-O-alpha-L-rhamnopyranosyl-7-O-alpha-L-rhamnopyranoside;3,7-Bis((6-deoxy-α-L-mannopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Kaempferol 3,7-dirhamnoside;Lespedin;Lespenefril;Lespenephryl;3,7-bis[(6-deoxy-beta-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;[ "" ]
Cas No.	482-38-2
分子式	C₂₇H₃₀O₁₄
分子量	578.52
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性	Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway.
性状	Solid
IC50 & Target[1][2]	Insulin Receptor
体外研究(In Vitro)	Kaempferitrin activates insulin signaling pathway. Kaempferitrin causes survival rates higher than 90% at 1-20 μM in matured 3T3-L1 adipocyte, and the survival rates decline rapidly at 25 and 50 μM. Kaempferitrin (15 μM) increases insulin receptor beta tyrosine phosphorylation and tyrosine phosphorylation of the insulin receptor substrate 1, and such effects are similar to that of 10 nM insulin. Kaempferitrin (15 μM) also stimulates akt phosphorylation on ser473, and the stimulation can be blocked by a PI3-K inhibitor wortmannin. Kaempferitrin potently exerts the translocation of GLUT4 to the membrane of adipocytes at 15 μM, and this is suppressed by wortmannin. In addition, Kaempferitrin increases the total levels of Glu4 protein in differentiated cells and secreted adiponectin in mature 3T3-L1 adipocytes. Kaempferitrin is cytotoxic to human cancer cells such as HeLa and MDA-
体内研究(In Vivo)	Kaempferitrin (2.5, 10 and 25 mg/kg, i.p.) markedly suppresses the growth of tumor by 40%, 87% and 97%, and decreases tumor weight by 37%, 81% and 95%, respectively in nu/nu mice bearing HeLa tumor. Kaempferitrin also inhibits cell proliferation and extends life span in mice bearing tumor.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；
结构分类	Flavonoids Flavon
来源	Plants

溶解度数据	体外研究: DMSO : 25 mg/mL(43.21 mM;Need ultrasonic) 配制储存液

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