Cyclosporin A|59865-13-3|(环孢素; Cyclosporine A; Ciclosporin A; CsA)-陌孚医药/Medlife

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Cyclosporin A (Synonyms: 环孢素; Cyclosporine A; Ciclosporin A; CsA)

目录号: PC61643 纯度: ≥99%

CAS No. :59865-13-3

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中文名称	Cyclosporin A
中文别名	环孢素 A;环孢素;环胞霉素 A;环胞菌素;抗生素S;环胞霉素;环孢菌素A;环孢菌素;环孢菌素 USP标准品;环孢菌素(环孢素);环孢菌素,环孢霉素A;环孢菌素A,Cyclosporin A,植物提取物,标准品,对照品;环孢菌素A标准品;环孢菌素标准品(JP);环孢霉素A;环孢霉素A 标准品;环孢霉素A,BR;环孢素 EP标准品;环孢素（环孢素A）;环孢素-A;环孢素A标准品;环孢素系统适用性 EP标准品;环胞霉素A 标准品;[(E)(2S,3R,4R)-3-羟基-4-甲基-2-(甲氨基)-6辛烯酰]-L-2氨基丁酰-N-甲基甘氨酰-N-甲基-L-亮氨酰-L-缬氨酰-N-甲基-L-亮氨酰-L-丙氨酰-D-丙氨酰-N-甲基-L-亮氨酰-N-甲基-L-亮氨酰-N-甲基-L-缬氨酰;环孢多肽A;环孢菌素分离度用混合物;环孢灵;环孢素分离度用混合物;环蒽孢A;赛斯平;山地明;出地明;抗生素S 7481F1;环孢菌素环孢菌素环孢素环胞菌素;环孢素环孢菌素杂质;环孢菌素, 环孢素, 抗生素S 7481F1,环孢多肽A,环孢灵,出地明;环胞霉素A.环孢素A;环胞霉素A, 98%+;环孢菌素 A 溶液;环孢素A
英文名称	Cyclosporin A
英文别名	Cyclosporin A;Cyclosporin A (Cyclosporine ,Antibiotic S 7481F1,Ciclosporin A, Ramihyphin A,CsA);Cyclosporin A solution;CYCLOSPORIN A, TOLYPOCLADIUM INFLATUM;Cyclosporine;Cyclosporine A;Atopica;ciclosporin;ciclosporin A;Cipol N;Cyclosporin A from Tolypocladium inflatum;Cyclosporine Resolution Mixture;Neoplanta;Neoral;ol27-400;Optimmune;Restasis;s7481f1;sandimmun;sandimmun neoral;Sandimmun optoral;Cyclosporin;Antibiotic S 7481F1;Ciclosporine;Ciclosporinum;Ciclosporina;Sandimmune;Equoral;Gengraf;Consupren;Ramihyphin A;SangCyA;83HN0GTJ6D;MLS001333756;CSA;S-Neoral;Sang 35;DSSTox_CID_365;Ciclosporinum [INN-Latin];Ciclosporine [INN-French];Ciclosporina [INN-Spanish];DSSTox_RID_75541;Ciclosporin (Ciclo;sandimmune;Cyclospori;1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane, cyclic peptide deriv.;30-Ethyl-33-(1-hydroxy-2-methyl-hex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone;Ciclosporin;CsA
Cas No.	59865-13-3
分子式	C₆₂H₁₁₁N₁₁O₁₂
分子量	1202.61
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性

Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC₅₀ of 5 nM. Cyclosporin A also inhibits CD11a/CD18 adhesion.

性状

Solid

IC50 & Target[1][2]

IC50: 7 nM (calcineurin)

体外研究(In Vitro)

Cyclosporin A is able to bind with the cyclophilin in T cells. Cyclosporin A works by forming a Cyclophilin-Cyclosporin A complex to inhibit calcineurin. Cyclosporin A inhibits calcineurin in stimulated cells with an IC50 value of 7 nM. Cyclosporin A suppresses the nuclear translocation of NF-AT. Cyclosporin A shows an effect on mitochondria via preventing the MTP from opening with an IC50 of 39 nM.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Cyclosporin A has immunosuppressive activity, and is active via parenteral and p.o. administration in mice, rat and guinea pigs. Cyclosporin A can be used in organ transplantation to prevent rejection.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

ClinicalTrial

结构分类

Others

来源

the fungus Beauveria nivea.

溶解度数据	体外研究: DMSO : 62.5 mg/mL(51.97 mM;Need ultrasonic) Ethanol : 50 mg/mL(41.58 mM;Need ultrasonic) 配制储存液

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