Nicotinamide.|98-92-0|(烟酰胺; Niacinamide; Nicotinic acid amide)-陌孚医药/Medlife

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Nicotinamide. (Synonyms: 烟酰胺; Niacinamide; Nicotinic acid amide)

目录号: PC62821 纯度: ≥99%

CAS No. :98-92-0

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中文名称	Nicotinamide.
中文别名	烟酰胺;烟碱酰胺;维生素B3;维生素PP;尼克酰胺;3-吡啶甲酰胺;3-甲酰氨基吡啶;Nicotinamide；烟酰胺;Nicotinamide；烟酰胺标准品;维生素B3；烟酸胺;维生素B3；烟酰胺;维生素PP、烟酰胺;烟碱;烟酰胺；尼克酰胺;烟酰胺 EP标准品;烟酰胺 USP标准品;烟酰胺标准品;烟酰胺添加剂;烟酰胺；维生素B3;烟酰胺；4-吡啶甲酰胺;烟酰胺；Nicotinamide;烟酰胺（VPP）;烟酰胺（标准品）;烟酰胺(维生素B3);烟酰胺(维生素B3) 标准品;烟酰胺；3-吡啶甲酰胺;烟酰胺,AR;烟酰胺,对照品;烟酰胺；五味子酯甲；五味子醇乙；西红花苷；西红花苷II;烟酰胺标准品(JP);尼古丁酰胺;食品助色剂、营养增补剂;维生素PP,烟酰胺;烟碱酰胺,3-吡啶甲酰胺,尼古丁酰胺;烟酰胺；烟碱酰胺;菸酰胺;吡啶-3-甲酰胺;维生素 B3;维生素 PP
英文名称	Nicotinamide
英文别名	Nicotinamide;VB3;VPP;Pyridine-3-carboxamide;niacinamide cell culture tested;Nicotinamide (1.06818);Niacinamide;Vitamin PP;Pyridine-3-Carboxyamide;3-Pyridinecarboxamide;Nicotinamide (Niacinamide);Nicotinamide (Vitamin B3);Nicotinamide (Vitamin B3) solution;VITAMIN B3(NIACINAMIDE)(P) PrintBack;VITAMIN B3(NIACINAMIDE)(SH);Nicotinamide INCI;3-Pyridinecarboxylic acid aMide;Nicotinic acid amide;Vitamin B3;3-Pyridinecarboxamide;Papulex;Nicobion;Amixicotyn;Aminicotin;Nicotylamide;Savacotyl;Nikotinamid;Pelmine;Dipegyl;Benicot;Hansamid;Endobion;Nicotinic amide;Delonin amide;Pelonin amide;Vi-Nicotyl;Austrovit PP;Inovitan PP;Vitamin B;Nicotililamido;Nicotilamide;Nicosylamide;Nicotamide;Nicovitina;Niocinamide;Nicozymin;Amnicotin;Niozymin;Nicovitol;Nicomidol;Nicofort;Nicamindon;Nicamina;Niacevit;Nicovit;Nicasir;Nicoge
Cas No.	98-92-0
分子式	C₆H₆N₂O
分子量	122.12
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性

Nicotinamide is a form of vitamin B3 or niacin that inhibits sirtuin 2 (SIRT2) activity in vitro, with an EC₅₀ of 2 μM. Nicotinamide inhibits up to 90% melanoma cell number and increases cellular NAD₊, ATP, ROS levels. Nicotinamide inhibts tumor growth in vivo and improves survival of melanoma-bearing mice, which can be used for the research of skin cancers such as melanoma.

性状

Solid

IC50 & Target[1][2]

PARP-1
Human Endogenous Metabolite

体外研究(In Vitro)

Nicotinamide (0-50 mM, 24/48 h ) reduces cell number in a time-dependent and dose-dependent manner in A375 andSK-MEL-28 cells.
Nicotinamide (10-50 mM, 24 h ) makes A375 cells undergo accumulation in G1 phase, reduction in S phase, and increase inthe sub-G1 (apoptosis) phase.
Nicotinamide (1-50 mM, 6 h ) increases NAD+, ATP and ROS levels in A375 and SK-MEL-28 cells.
Nicotinamide (0.01-20 mM, 1 h) inhibits purified SIRT2 enzymatic activity in vitro with an EC50 of 2 μM.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Nicotinamide (Intraperitoneal injection, 1500 and 1800 mg/Kg, 5 days per week) inhibits tumor growth in murine metastatic melanoma model.
Nicotinamide (Intraperitoneal injection, 1800 mg/Kg, once a day, murine metastatic melanoma model) affects IFN-γ (a key mediator of cell-mediated anti-tumor immunity), increases the plasma levels of eotaxin and IL-5, reduces the plasma levels of IL-3, IL-12, RANTES and IL-10.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

ClinicalTrial

结构分类

Alkaloids
Pyridin

溶解度数据	体外研究: DMSO : 50 mg/mL(409.43 mM;Need ultrasonic) H₂O : ≥ 50 mg/mL(409.43 mM) *≥ means soluble, but saturation unknown.

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