Ginsenoside Rb3.|68406-26-8|(人参皂苷 Rb3; Gypenoside IV)-陌孚医药/Medlife

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Ginsenoside Rb3. (Synonyms: 人参皂苷 Rb3; Gypenoside IV)

目录号: PC64174 纯度: ≥99%

CAS No. :68406-26-8

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中文名称	Ginsenoside Rb3.
中文别名	人参皂甙 Rb3;人参皂甙 Rb3 Ginsenoside Rb3;人参皂甙 Rb3 大黄酚芦荟大黄素杨梅素;人参皂甙 Rb3(标准品);人参皂苷 Rb3;人参皂苷 Rb3(P);人参皂苷Rb3 标准品;人参皂苷Rb3,Ginsenoside-Rb3,植物提取物,标准品,对照品;人参皂苷Rb3对照品;三七叶皂苷;人参皂苷Rb3(人参皂荚RB2,人参皂甙 RB3);人参皂苷Rb3
英文名称	Ginsenoside Rb3
英文别名	ginsenoside rb3;GINSENOSIDE Rb3(P) PrintBack;Ginsenoside-Rb3;Gypenoside IV;(20S)-3;3-epicabraleahydroxylactone;A,20S)-3-(Acetyloxy)pregn-5-ene-20-carboxaldehyde;A-Acetoxy-22,23-dinorchol-5-en-24-al;A-Acetoxybisnor-5-cholen-22-al;A-Acetoxypregn-5-ene-20-carboxaldehyde;ginsenoside-RB2;(3β,12β)-3-[(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl 6-O-β-D-xylopyranosyl-β-D-glucopyranoside;Dammarane,b-D-glucopyranoside deriv.
Cas No.	68406-26-8
分子式	C₅₃H₉₀O₂₂
分子量	1079.27
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Ginsenoside Rb3 is extracted from steamed Panax ginseng C. A. Meyer. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.
性状	Solid
IC50 & Target[1][2]	NF-κB 8.2 μM (IC50, in 293T cell lines)iNOS &
体外研究(In Vitro)	Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL). Ginsenoside Rb3 (0.1-10 μM) significantly increases cell viability and inhibits lactate dehydrogenase (LDH) release in a dose-dependent manner. PC12 cell viability as determined by MTT reduction is also markedly decreased after the cell is exposed to oxygen and glucose deprivation (OGD)/OGD-Rep. But, when the cells are pretreated wi
体内研究(In Vivo)	Ginsenosides Rb3 is a major compound isolated from Gynostemma pentaphyllum that holistically improves gut microenvironment and induces anti-polyposis in Apc mice. Six-weeks-old mice are subjected to Rb3 treatment, before the appearance of the intestinal polyps. All the mice are monitored for food intake, water consumption, and weight changes. Throughout the experiment, no Rb3/Rd-associated weight loss in mice is observed. In addition, none of the treated mice show variations in food and water consumption. Whereas, the number and size of the polyps are effectively reduced by Rb3 treatments.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Terpenoids Triter
来源	Plants

溶解度数据	体外研究: DMSO : 100 mg/mL(92.66 mM;Need ultrasonic) 配制储存液

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