NADH disodium salt|606-68-8|(Disodium NADH)-陌孚医药/Medlife

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NADH disodium salt (Synonyms: Disodium NADH)

目录号: PC61674 纯度: ≥99%

CAS No. :606-68-8

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中文名称	NADH disodium salt
中文别名	beta-烟酰胺腺嘌呤二核苷二钠;beta-烟酰胺腺嘌呤二核甙二钠;beta-NADH 二钠;辅酶 I 二钠;还原型辅酶I二钠盐;β-烟酰胺腺嘌呤二核苷酸二钠盐水合物,还原型[生物化学用];beta-烟酰胺腺嘌呤二核苷二钠NADH;NADH Na2 还原型辅酶Ⅰ二钠;NADH Na2（NADH 一般都是带Na的）还原型辅酶Ⅰ二钠;β-二磷酸吡啶核苷酸钠盐;β-烟酰胺腺嘌呤二核苷酸;β-烟酰胺腺嘌呤二核苷酸二钠;β-烟酰胺腺嘌呤二核苷酸二钠盐, 还原型;辅酶I还原型;还原辅酶Ⅰ二钠盐;还原型 β-烟酰胺腺嘌呤二核苷酸二钠盐水合物;还原型辅酶Ⅰ;还原型辅酶Ⅰ二钠;还原型辅酶Ⅰ二钠,三水;还原型辅酶Ⅰ二钠盐 beta-烟酰胺腺嘌呤二核苷二钠;还原型辅酶I;还原型辅酶I 二钠(β-NADH);还原型辅酶I,钠盐;还原型辅酶I二钠(NADH);还原型辅酶I二钠盐(β-NADH);还原性辅酶I二钠盐;硝基乙酰胺维生素B4;beta-烟酰胺腺嘌呤二核苷酸二钠盐水合物;β-烟酰胺腺嘌呤二核苷酸二钠盐水合物;还原型辅酶Ⅰ,二钠盐;β-DPNH二钠盐水合物 (还原型);β-NADH二钠盐水合物 (还原型);辅酶I二钠盐水合物 (还原型);辅酶二钠盐水合物 (还原型);还原型 β-烟酰胺腺嘌呤二核苷酸二钠盐
英文名称	NADH disodium salt
英文别名	beta-Nicotinamide adenine dinucleotide disodium salt;beta-NADH disodium salt;β-NADH;beta-Nicotinamide Adenine Dinucleotide Disodium Salt Hydrate, reduced form[for Biochemical Research];Disodium NADH;NADH;NADH (sodium salt);Nicotinamide adenine dinucleotide (reduced) disodium salt (NADH 2Na);β-NADH Disodium Salt;β-Nicotinamide adenine dinucleotide disodium salt;beta-NicotinaMide adenine dinucleotide;β-DPNH;Coenzyme I reduced disodium salt;Diphosphopyridine nucleotide reduced disodium salt;Coenzyme I Disodium Salt Hydrate, reduced form;Cozymase Disodium Salt Hydrate, reduced form;β-Diphosphopyridine Nucleotide Disodium Salt Hydrate, reduced form;β-DPNH Disodium Salt Hydrate, reduced form;β-NADH Disodium Salt Hydrate, reduced form; NADH disodium salt ; Disodium NADH; Adenosine 5'-(trihydrogen pyrophosphate), 5'→5'-ester with 1,4-dihydro-1-β-D-ribofuranosylnicotinamide, disodium salt (8CI);Adenosine 5'-(trihydrogen diphosphate), P'→5'-ester with 1,4-dihydro-1-β-D-ribofuranosyl-3-pyridinecarboxamide, disodium salt (9CI);Adenosine 5'-(trihydrogen diphosphate), P'→5'-ester with 1,4-dihydro-1-β-D-ribofuranosylnicotinamide, sodium salt (1:2);NADH disodium salt
Cas No.	606-68-8
分子式	C₂₁H₂₇N₇Na₂O₁₄P₂
分子量	709.41
包装储存	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性	NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle.
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite

体外研究(In Vitro)

NADH is unstable under acidic conditions but it is stable under alkaline conditions.
NADH (0-1 mM; 0-12 h) increases NAD levels in various mammalian cell lines.
NADH (1 mM; 24 h) causes low toxicity and protects cells from genotoxicity.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

NADH (5 μmol/mouse; i.p.; once) increases urinary excretion of nicotinamide and its metabolites in mice.
NADH (500 mg/kg; i.g.; once) promotes alcohol metabolism and prevents or ameliorates early liver injury caused by acute alcohol exposure in ethanol-loaded mice.
NADH (1000 mg/kg; i.p.; once) enhances tissue NAD levels in male C57BL/6J mice.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

结构分类

Others

溶解度数据	体外研究: H₂O : ≥ 100 mg/mL(140.96 mM) DMSO : 100 mg/mL(140.96 mM;Need ultrasonic) *≥ means soluble, but saturation unknown.

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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