ATP (Adenosine 5-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
性状
Solid
IC50 & Target[1][2]
Human Endogenous Metabolite
体外研究(In Vitro)
ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner.ATP promotes neutrophil chemotaxis in vitro.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.Animal Model:
运输条件
Room temperature or refrigerated transport.
储存方式
Powder; -20°C; 3 years; 4°C; 2 years;
结构分类
AlkaloidsOther A
来源
Plantsother fami
溶解度数据
体外研究:H2O : ≥ 100 mg/mL(197.17 mM)*≥ means soluble, but saturation unknown. 配制储存液