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Aphidicolin (Synonyms: 阿非迪霉素)
目录号: PC64070 纯度: ≥99.0%
CAS No. :38966-21-1
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PC64070-1mg 1mg 询价 询价
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中文名称
Aphidicolin
中文别名
8,11伪-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-;艾菲地可宁;(+)-阿非迪霉素;8,11伪-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-...;阿非迪霉素;阿非科林
英文名称
Aphidicolin
英文别名
(+)-Aphidicolin;(+)-Aphidicolin (NSC234714, BRN4689958, ICI69653 );ALLOPHYCOCYANIN;Aphidicolin;9-dimethanol,tetradecahydro-3,9-11a-methano-11ah-cyclohepta(a)naphthalene-4;APC;Apchidicolin;Aphidicholin;Aphidicolin from Nigrospora sphaerica;aphidocolin;ICI 69653;NSC 234714;NSC234714;MLS000069677;192TJ6PP19;SMR000058538;8,11
Cas No.
38966-21-1
分子式
C20H34O4
分子量
338.48
包装储存
Powder; -20°C; 3 years;In solvent; -80°C; 6 months;
生物活性
Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
性状
Solid
体外研究(In Vitro)
Aphidicolin (0.5 μM, 5 μM; 0-5 d) selectively kills neuroblastoma cells, but shows moderate cytotoxicity on normal human embryonal cells and HeLa, H9, A549 and Caco-2 cell lines.
Aphidicolin (0.4 μg/mL; 3 d) arrests cell cycle at G2 phase.
Aphidicolin (100 nM-10 μM; 48 h) inhibits cell proliferation via the p53-GADD45β pathway and (1 μM; 24 h) induces apoptosis in AtT-20 cells.
Aphidicolin (10 μM; 0-6 h) decreases the phosphorylation of Akt, (100 nM-10 μM; 24 h) increases the mRNA levels of the stress response gene growth arrest and DNA damage-inducible 45β (GADD45β), a putative downstream target of p53.
Aphidicolin (10 μM; 0-6 h) inhibits Varicella-zoster virus (VZV) with EC50s of 0.5-0.6 μM, with low cytotoxicity.
Medlife has not independently confirmed the accuracy of these methods. They are fo
体内研究(In Vivo)
Aphidicolin, has been developed with higher solubility agent, namely Aphidicolin glycinate (AG; NSC 303812).
Aphidicolin glycinate (100 mg/kg; i.p.; once every 3 h; 9 d) shows anti-tumor activity against the implanted B16 melanoma and M5076 sarcoma in murine, producing maximum increased life spans of 75%.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
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运输条件
Room temperature or refrigerated transport.
储存方式
Powder; -20°C; 3 years;In solvent; -80°C; 6 months;
结构分类
Terpenoids
Diterp
来源
Cephalosporium aphidicola
溶解度数据
体外研究:
DMSO : 50 mg/mL(147.72 mM;Need ultrasonic and warming)
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

The molarity calculator equation
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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