Rapamycin.|53123-88-9|(雷帕霉素; 西罗莫司; Sirolimus; AY-22989)-陌孚医药/Medlife

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Rapamycin. (Synonyms: 雷帕霉素; 西罗莫司; Sirolimus; AY-22989)

目录号: PC61231 纯度: ≥99%

CAS No. :53123-88-9

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中文名称	Rapamycin.
中文别名	雷帕霉素;Rapamicin（sirolimus ）抑制剂;Rapamycin 雷帕霉素;Sirolimus 雷帕霉素标准品;Sirolimus,certified 标准品;雷帕霉素 (西罗莫司、瑞帕霉素);雷帕霉素西罗莫司;雷帕霉素(西罗莫司);雷帕霉素,Rapamycin;西罗莫司;西罗莫司（雷帕霉素）;西罗莫司(雷帕霉素) 标准品;西罗莫司,Sirolimus,植物提取物,标准品,对照品;西罗莫司标准品;间苯二酚;雷帕酶素;雷帕霉素西罗莫司Rapamycin,Sirolimus;雷帕霉素雷帕霉素,Sirolimus;雷帕霉素：西罗莫司;瑞帕霉素;雷帕霉素来源于吸水链霉菌
英文名称	Rapamycin
英文别名	rapamycin from streptomyces*hygroscopicus;23,27-EPOXY-3H-PYRIDO(2,1-C)(1,4)OXAAZACYCLOHENTRIACONTINE;AY 22989;NSC-226080;RAPA;RAPAMUNE;RAPAMYCIN;RAPAMYCIN, STREPTOMYCES HYGROSCOPICUS;RPM;SIROLIMUS;antibioticay22989;sila9268a;WYETH RAPAMYCIN, 1GM;RAPAMYCIN 1GM;RAPAMYCIN, STANDARD WITH MS, NMR RESULT;Rapamicin;Rapamicin（sirolimus ）;Rapamycin (AY 22989, Sirolimus, RAPA,NSC 226080, Rapamune®);Rapamycin (Sirolimus);Sirolimus solution;Siroliums; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine,AY 22989,Sirolimus;Rapamycin from Streptomyces hygroscopicus;Resorcinol;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine;(-)-Rapamycin;Rapammune;sirolimusum;Antibiotic AY 22989;SILA 9268A;W36ZG6FT64;C51H79NO13;DSSTox_CID_3582;DSSTox_RID_77091;DSSTox_GSID_23582;Cypher;Supralimus;Wy 090217;I 2190A;I2190A;SIIA 9268A
Cas No.	53123-88-9
分子式	C₅₁H₇₉NO₁₃
分子量	914.17
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.

性状

Solid

IC50 & Target[1][2]

mTOR
0.1 nM (IC50, in HEK293 cells )Microbial Metabolite

体外研究(In Vitro)

Rapamycin (12.5-100 nM; 24 hours) treatment exerts modest inhibitory effect on lung cancer cell proliferation in a dose-dependent manner in all cell lines (A549, SPC-A-1, 95D and NCI-H446 cells) tested, achieving about 30-40% reduction in cell proliferation at 100 nM vs. ~10% reduction at 12.5 nM.
Lung cancer cell line 95D cells are exposed to Rapamycin (10 nM, 20 nM) and RP-56976 (1 nM, 10 nM) alone or in combination (Rapamycin 20 nM+ RP-56976 10 nM). After 24 hours exposure to Rapamycin or RP-56976 alone does not significantly alter the level of expression or phosphorylation of ERK1/2, whereas cells treated with the combination of Rapamycin with RP-56976 exhibit a marked reduction in the phosphorylation levels of ERK1/2.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

雷帕霉素(2.0 mg/kg;腹腔内注射;每隔一天;28天)单独使用有中等的抑制作用。然而，与对照组、雷帕霉素单药组相比，二甲双胍联合雷帕霉素对肿瘤生长的抑制作用明显增强。Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:24 male nu/nu mice aged 4-5 week o

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Antibiotics
Macro

来源

bacterium Streptomyces hygroscopicus

溶解度数据	体外研究: DMSO : 125 mg/mL(136.74 mM;Need ultrasonic) Ethanol : 50 mg/mL(54.69 mM;Need ultrasonic) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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