Ellipticine hydrochloride|5081-48-1|(玫瑰树碱盐酸盐; NSC 71795 hydrochloride)-陌孚医药/Medlife

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Ellipticine hydrochloride (Synonyms: 玫瑰树碱盐酸盐; NSC 71795 hydrochloride)

目录号: PC62930 纯度: ≥99%

CAS No. :5081-48-1

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中文名称	Ellipticine hydrochloride
中文别名	Ellipticine (hydrochloride);玫瑰树碱盐酸盐
英文名称	Ellipticine hydrochloride
英文别名	Ellipticine, Monohydrochloride;Ellipticine (hydrochloride);Ellipticine hydrochloride
Cas No.	5081-48-1
分子式	C₁₇H₁₅ClN₂
分子量	282.77
包装储存	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性	Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
性状	Solid
IC50 & Target[1][2]	Topoisomerase II

体外研究(In Vitro)

Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts.

体内研究(In Vivo)

Ellipticine (NSC 71795) treatment results in ellipticine-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795).Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

结构分类

Alkaloids
Indole

来源

Plants

溶解度数据	体外研究: DMSO : 5.8 mg/mL(20.51 mM;Need ultrasonic and warming) H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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