Scopolamine|51-34-3|(东莨菪碱; Hyoscine; Scopine (-)-tropate; Scopine tropate)-陌孚医药/Medlife

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Scopolamine (Synonyms: 东莨菪碱; Hyoscine; Scopine (-)-tropate; Scopine tropate)

目录号: PC62923 纯度: ≥99%

CAS No. :51-34-3

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中文名称	Scopolamine
中文别名	东莨菪碱;9-甲基-3-氧杂-9-氮杂三环[3.3.1.02,4]壬烷-7-醇 (-)-alpha-(羟甲基)苯乙酸酯;Scopolamine；东莨菪碱标准品;东莨(lang)菪(dang)碱;东莨宕碱；东莨菪碱;东莨宕碱；东莨菪碱；天仙子碱;东莨菪碱对照品;氢溴酸东莨菪碱；氢溴酸东莨菪碱
英文名称	Scopolamine
英文别名	Scopolamine;9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol (-)-alpha-(hydroxymethyl)benzeneacetate;Hyoscine;LCZ696;Scopine (-)-tropate;Scopine tropate;(-)-Hyoscine;Transderm-Scop;6,7-Epoxytropine tropate;(-)-Scopolamine;Isopto Hyoscine;Hyosol;6-beta,7-beta-Epoxy-3-alpha-tropanyl S-(-)-tropate;Atroquin;Atrochin;Oscine;Transderm scop;Epoxytropine tropate;alpha-(Hydroxymethyl)benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester;Skopolamin;l-Scopolamine;DL48G20X8X;(1S,3S,5R,6R,7S)-6,7-epoxytropan-3-yl (2S)-3-hydroxy-2-phenylpropanoat
Cas No.	51-34-3
分子式	C₁₇H₂₁NO₄
分子量	303.35
包装储存	4°C, Sealed and stored away from moisture and light；*In solvent : -80°C, 6 months; -20°C, 1 month (Sealed and stored away from moisture and light)；

生物活性	Scopolamine is a high affinity (nM) muscarinic antagonist. 5-HT₃ receptor-responses are reversibly inhibited by Scopolamine with an IC₅₀ of 2.09 μM.
性状	Viscous liquid
IC50 & Target[1][2]	5-HT3 Receptor 2.09 μM (IC50)Human Endogenous Metabolite
体外研究(In Vitro)	Application of Scopolamine to oocytes expressing 5-HT3 receptors does not elicit a response when applied alone, but causes a concentration-dependent inhibition of the response during a co-application of 2 μM 5-HT. The pIC50 value for Scopolamine is 5.68±0.05 (IC50=2.09 μM, n=6) with a Hill Slope of 1.06 ± 0.05. This gave a Kb of 3.23 μM. The same concentration-dependent effect is also seen when Scopolamine is applied during the 5-HT application. To further test for a competitive binding at the 5-HT3 receptor, the competition of unlabelled Scopolamine is measured with [H]granisetron, an established high-affinity competitive antagonist at these receptors. Scopolamine displays concentration-dependent competition with 0.6 nM [H]granisetron (~Kd), yielding an average pKi of 5.17±0.24 (Ki=6.76 μM
体内研究(In Vivo)	In the histopathology study, there is no significant change in the histology of the brain. However, it is observed that there is a reduction in density of cells in the hippocampus of the control mice pretreated with Scopolamine who received only distilled water. Scopolamine administration alone significantly increases the activity of Acetylcholinesterase enzyme (AchE) (7.98±0.065; P<0.001) when compared to the normal group (3.06±0.296). The animals treated with Scopolamine report a significant increase (34.61±4.85; P<0.01) in levels of malondialdehyde (MDA) as compared to the normal group (12.82±2.86). The Scopolamine-treated group shows significant decrease in reduced glutathione (GSH) level (P<0.001; 0.1504±0.03) as compared to the normal group (0.3906±0.02). The Scopolamine-treated rats show a significant increase in the concentration ofβ amyloid (Aβ1-42
运输条件	Room temperature or refrigerated transport.
储存方式	4°C, Sealed and stored away from moisture and light；*In solvent : -80°C, 6 months; -20°C, 1 month (Sealed and stored away from moisture and light)；
结构分类	Alkaloids Other A
来源	Plants

溶解度数据	体外研究: DMSO : 100 mg/mL(329.65 mM;Need ultrasonic) 配制储存液

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