Rhapontigenin|500-65-2|(丹叶大黄素)-陌孚医药/Medlife

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Rhapontigenin (Synonyms: 丹叶大黄素)

目录号: PC58164 纯度: ≥99%

CAS No. :500-65-2

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中文名称	Rhapontigenin
中文别名	丹叶大黄素;土大黄苷元;(E)-5-[2-(3-羟基-4-甲氧基苯基)乙烯基]-1,3-苯二酚;Rhapontigenin 丹叶大黄素;丹叶大黄素对照品;四氢吡喃-4,4-二羧酸二甲酯;(E)-4'-甲氧基-3,3',5-三羟基苯乙烯;丹叶大黄素,(E)-4'-甲氧基-3,3',5-三羟基苯乙烯
英文名称	Rhapontigenin
英文别名	1,3-Benzenediol,5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-;(E)-5-(3-Hydroxy-4-methoxystyryl)benzene-1,3-diol;RHAPONTIGENIN;3,3',5-Trihydroxy-4'-methoxy-trans-stilbene;trans-1-(3,5-Dihydroxyphenyl)-2-(3-hydroxy-4-methoxyphenyl)ethylene;Pontigenin;Prontigenin;Protigenin;Rhapontin aglycone;Rhapontin genin;(E)-5-[2-(3-Hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol;3,3',5-trihydroxy-4'-methoxystilbene;5-[(E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]benzene-1,3-diol;PHMHDRYYFAYWEG-NSCUHMNNSA-N;HMS3648K18;BCP15039;4-Methoxystilbene-3,3',5'-triol;2027AH;AK162489;AX8161469;ST24035068;R0089;500R652
Cas No.	500-65-2
分子式	C₁₅H₁₄O₄
分子量	258.27
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性	Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC₅₀ = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively.
性状	Solid
IC50 & Target[1][2]	CYP1A1 400 nM (IC50)

体外研究(In Vitro)

Rhapontigenin (0-250 μM; 24 hours) demonstrates concentration-dependent anti-cancer activity with an IC50 115μM in HEP G2 cells.
Rhapontigenin (20 μM; 20 hours) pre-treatment decreases TGF-β triggered increased snail expression in diverse cancer cells.
Rhapontigenin (0-20 μM; 6 hours) inhibits TGF-β-induced expression of N-cadherin, vimentin, and CA9 in a dose-dependent manner.
Rhapontigenin inhibits ADP- and collagen-induced platelet aggregation with IC50 values of 4 and 70 μg/ml, respectively.
Rhapontigenin demonstrates a strong inhibitory activity on the 13-hexosaminidase release induced by DNP-BSA, it exhibits IC50 value of 0.03 mM in RBL 2H3 cells.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Rhapontigenin (intraperitoneal injection; 25mg/kg) shows significant protection from death due to pulmonary thrombosis in mice, those samples are orally administered 90 min before tail vein injection of epinephrine and collagen.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
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运输条件

Room temperature or refrigerated transport.

储存方式

4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

结构分类

Phenols
Polypheno

来源

Plants

溶解度数据	体外研究: DMSO : 125 mg/mL(483.99 mM;Need ultrasonic) 配制储存液

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Data Sheet

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