Fosbretabulin disodium|168555-66-6|(康普瑞汀磷酸二钠; CA 4DP; CA 4P; Combretastatin A4 disodium phosphate)-陌孚医药/Medlife

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Fosbretabulin disodium (Synonyms: 康普瑞汀磷酸二钠; CA 4DP; CA 4P; Combretastatin A4 disodium phosphate)

目录号: PC58162 纯度: ≥99%

CAS No. :168555-66-6

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中文名称	Fosbretabulin disodium
中文别名	康普瑞汀磷酸二钠;康普瑞汀磷酸二钠盐;康普瑞汀A4磷酸二钠;苯酚磷酸酯二钠盐;康布瑞汀磷酸二钠;康普瑞汀;考布他丁 A-4 磷酸二钠盐;考布他丁 A-4 磷酸二钠盐康普瑞丁磷酸二钠;2-甲氧基-5-[(1Z)-2-(3,4,5-三甲氧基苯基)乙烯基]苯酚磷酸酯二钠盐;康普瑞汀磷酸酯二钠;考布他丁磷酸二钠;康布瑞汀;福他布林;康普瑞丁磷酸二钠;康普瑞汀A-4磷酸二钠盐
英文名称	Fosbretabulin disodium
英文别名	Combretastatin A4 disodium phosphate;2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol dihydrogen phosphate disodium salt;Combretastatin A4 Phosphate Disodium Salt;Fosbretabulin disodium;COMBRETASTATIN A-4 PHOSPHATE, DISODIUM SALT;disodium,[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate;Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium;CA 4P;CA4DP;Combretastatin A-4 phosphate;Fosbretabulin disodium (USAN);Fosbretabulin disodium salt;Zybrestat;2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl disodium phosphate;Combretastatin A4 phosphate disodium;Fosbretabulin (disodiuM);CoMbretastatin A4 disodiuM;Fosbretabulin disodiuM (CA4P);CoMbretastatin A4 Phosphate(CA4P);CA-4P, Combretastatin A-4 phosphate;CA4P;PHE022;AOB2521;Combretastatin A4 Phosphate (CA4P);Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-,1-(dihydrogen phosphate), sodium salt (1:2);Disodium;[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate;Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, 1-(dihydrogen phosphate), sodium salt (1:2)
Cas No.	168555-66-6
分子式	C₁₈H₂₁NaO₈P
分子量	419.32
包装储存	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性

Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 prodrug that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis.

性状

Solid

IC50 & Target[1][2]

tubulin

体外研究(In Vitro)

Fosbretabulin disodium inhibits growth of leukemia P-388, pancreas BXPC-3,neuroblast SK-N-SH, thyroid SW1736, lung-NSC NCI-H460, prostate DU-145, an pharynx FADU, with EC50s of 0.0029, 0.23, 0.00025, 0.00061, 0.00035, 0.00072, and 0.00045 μg/mL, respectively.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Fosbretabulin disodium (100 mg/kg; i.p.) increases the mean arterial blood pressure (MABP) at 1 and 6 h after administration and decreases the tumor blood flow in rats.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

ClinicalTrial

结构分类

Stilbenes

来源

Plants
other fami

溶解度数据	体外研究: H₂O : 4.5 mg/mL(10.22 mM;Need ultrasonic and warming) DMF : 1 mg/mL(2.27 mM;Need ultrasonic) DMSO : < 1 mg/mL (insoluble or slightly soluble)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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