Emodin.|518-82-1|(大黄素; Frangula emodin)-陌孚医药/Medlife

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Emodin. (Synonyms: 大黄素; Frangula emodin)

目录号: PC58226 纯度: 10mM*1mL in DMSO

CAS No. :518-82-1

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中文名称	Emodin.
中文别名	大黄素;朱砂莲甲素;1,3,8-三羟基-6-甲基蒽醌;大黄素,泻素;2-甲基-4,5,7-三羟基蒽醌;6-甲基-1,3,8-三羟基蒽醌;大黄素(泻鼠李树皮);泻素;大黄素对照品;大黄素对照品标准品;大黄素标准品;大黄素植物提取物,标准品,对照品;大黄素提取物;大黄素中药对照品;何首乌提取物;决明子提取物;青蒿提取物;朱砂莲甲素植物提取物,标准品,对照品;1,3,8-三羥-6-甲蒽醌;1'3'8-三羟基-6-甲基蒽醌;大黄酸;何首乌;朱砂莲甲素.1'3'8-三羟基-6-甲基蒽醌;大黄素，朱砂莲甲素
英文名称	Emodin
英文别名	Emodin;1,3,8-Trihydroxy-6-methylanthraquinone;6-Methyl-1,3,8-trihydroxyanthraquinone;emodin from frangula bark;2-CHLOROPYRIDINE-3-BORONIC ACID;EMODIN(P);EMODIN(P) PrintBack;EMODIN(RG);Frangula emodin;1,3,8-trihydroxy-6-methyl-9,10-anthraquinone;1,3,8-TRIHYDROXY-6-METHYL-9-10-ANTHRACENEDIONE;1,3,8-Trihydroxy-6-methylanthracene-9,10-dione;1,3,8-Tri-hydroxy-6-methyl-anthra-quinone;Alatinone;Archin;Ecdyson;Emdin;EMODIN 99;EMODINE;EMODOL;schuttgelb;1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione;1,3,8-Trihydroxy-6-methylanthraquinone;6-Methyl-1,3,8-trihydroxyanthraquinone;Frangula-emodin;Frangulic acid;Rheum emodin;C.I. 75440;C.I. Natural Yellow 14;[ "1", "3", "8-Trihydroxy-6-methylanthraquinone" ];1;3-Methyl-1,6,8-trihydroxyanthraquinone;Persian Berry Lake;9,10-Anthracenedione, 1,3,8-trihydroxy-6-methyl-;4,5,7-Trihydroxy-2-methylanthraquinone;NS
Cas No.	518-82-1
分子式	C₁₅H₁₀O₅
分子量	270.24
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively.Emodin ameliorates metabolic disorder in diet-induced obese mice.

性状

Solid

IC50 & Target[1][2]

SARS-CoV
CK2α Wild-type
1.4 μM (IC50, at ATP concentration is 10 μM)

体外研究(In Vitro)

Emodin (10-400 μM) blocks the binding of S protein to ACE2 in a dose-dependent manner with the IC50 value of 200 μM.
Emodin (5-50 μM) inhibits the S protein-pseudotyped retrovirus infectivity in a dose-dependent manner. Emodin blocks the SARS-CoV S protein binding to Vero E6 cells.
Emodin inhibits casein kinase-2 (CK2) with IC50s of 5.9, 30.0, and 7.1 μM for CK2α Wild-type, Ile174Ala mutant, and His160Ala mutant at ATP concentration is 50 μM, respectively. The IC50s are 1.40 and 38.00 μM for CK2α Wild-type, and Val66Ala mutant at ATP concentration is 10 μM.
Emodin exhibits low inhibitory activity against mouse and human 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), with an IC50 higher than 1 mM, indicating that Emodin is more than 5000-fold selective for the human and mouse 11β-HSD1 enzymes over the type 2 isoenzym

体内研究(In Vivo)

Emodin (single oral administration of 100 or 200 mg/kg) inhibits 11β-HSD1 activity in normal C57BL/6J male mice.
Emodin (100 mg/kg; oral administration; b.i.d.) improves insulin sensitivity and lipid metabolism, and lowers blood glucose and hepatic PEPCK, and glucose-6-phosphatase mRNA in diet-induced obese (DIO) mice.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Quinones
Anthraqu

来源

Plants

溶解度数据	体外研究: Acetone : 10.87 mg/mL(40.22 mM;Need ultrasonic) Ethanol : 10.87 mg/mL(40.22 mM;Need ultrasonic) DMSO : 5.41 mg/mL(20.02 mM;Need ultrasonic)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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