Quercetin dihydrate.|6151-25-3|(槲皮素,二水; 二水槲皮素)-陌孚医药/Medlife

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Quercetin dihydrate. (Synonyms: 槲皮素,二水; 二水槲皮素)

目录号: PC58328 纯度: 10mM*1mL in DMSO

CAS No. :6151-25-3

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中文名称	Quercetin dihydrate.
中文别名	二水槲皮素;二水栎精;二水槲皮黄素;栎精二水合物;槲皮素,二水合物;槲皮素,二水;二水合槲皮素(P);二水槲皮;二水槲皮素, 3,3',4',5,7-五羟基黄酮二水合物;二水槲皮素,槲皮素[槐米提取物];槲黄素,栎精,槲皮素;槲黄素二水合物;槲皮素;槲皮素 Quercetin;槲皮素 USP标准品;槲皮素(SH);槲皮素二水合物 EP标准品;芦丁杂质C(EP) 标准品;鼠李糖;3,3′,4′,5,7-五羟-2-苯基-1-氧杂-4-萘酮;3,5,7,3′,4′-五羟基-2-苯基苯并-4-吡喃酮;3,5,7,3′,4′-五羟基黄色素;3,5,7,3′,4′-五羟基黄酮;栎精酸;栎皮黄素;楝精;橡精;2-(3,4-二羟苯基)-3,5,7-三羟基-4H-1-苯并吡喃-4-酮二水合物;3,3′,4′,5,7-五羟基黄酮二水合物;3,3',4',5,7-五羟基黄酮二水合物;槲皮素二水合物;槲皮素二水合物
英文名称	Quercetin dihydrate
英文别名	2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one dihydrate;3,3,4,5,7-Pentahydroxyflavone hydrate;3,3,4,5,7-pentahydroxy-2-phenyl-4H-chromen-4-one dihydrate;Quercetin hydrate;3,3,4,5,7-Pentahydroxy-flavone dihydrate;Quercetin Dihydrate;Quercetin;QUERCETIN DIHYDRATE(AS) PrintBack;QUERCETIN DIHYDRATE(RG);Quercetin-d3 (Major);3,3`,4`,5,7-Pentahydroxyflavone dihydrate;3,3′,4′,5,7-Pentahydroxyflavone;Quercetinic acid;Sophoretin;3,3',4',5,7-Pentahydroxyflavone dihydrate;2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one dihydrate;Quercetine dihydrate;Quercetin, Dihydrate;Quercetin (dihydrate);Quercetin dihydrate (Sophoretin);Flavone, 3,3',4',5,7-pentahydroxy-, dihydrate;53B03V78A6;AK101905;DSSTox_CID_1219;3,3′,4′,5,7-Pentah
Cas No.	6151-25-3
分子式	C₁₅H₁₄O₉
分子量	338.27
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

性状

Solid

IC50 & Target[1][2]

PI3Kγ
2.4 μM (IC50)PI3Kβ
5.4 μM (IC5

体外研究(In Vitro)

Quercetin dihydrate is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits.
Quercetin dihydrate is a PI3K inhibitor with IC50s of 2.4-5.4 μM. Quercetin dihydrate strongly abrogates PI3K and Src kinases, mildly inhibits Akt1/2, and slightly affected PKC, p38 and ERK1/2.
Quercetin dihydrate inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Flavonoids
Flavon

来源

Plants
other fami

参考文献

[1]. Navarro-Nú?ez L, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80.
[2]. Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81.

溶解度数据	体外研究: DMSO : 100 mg/mL(295.62 mM;Need ultrasonic) H₂O : 1 mg/mL(2.96 mM;ultrasonic and warming and heat to 80°C) 配制储存液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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