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Salicylic acid (Synonyms: 水杨酸; 2-Hydroxybenzoic acid)

目录号: PC58330 纯度: ≥98.0%

CAS No. :69-72-7

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中文名称	Salicylic acid
中文别名	水杨酸;柳酸;邻羟基苯甲酸;2-羟基苯甲酸;2-羟基苯甲酸(升华级);水杨酸(工业级);水杨酸(升华级);水杨酸(医药级);2-Hydroxybenzoic Acid 2-羟基苯甲酸;2-Hydroxybenzoic Acid [for Biochemical Research] 2-羟基苯甲酸[生物学研究用];5-氨基-2-羟基苯甲酸;Sallcylic acid 水杨酸标准品;苯甲酸;工业水杨酸;磺基水杨酸;美沙拉嗪杂质H;纳米水杨酸;升华水杨酸;水杨酸 EP标准品;水杨酸 USP标准品;水杨酸标准品;水杨酸(P);水杨酸(RG);水杨酸,AR;水杨酸,CP;水杨酸,GCS;水杨酸,高纯;药用水杨酸;医药级水杨酸;乙酰水杨酸杂质C;氨基甲酸钙杂质C(EP);拉米夫定杂质C(EP);邻-羟基苯甲酸;柳氮磺胺嘧啶杂质H(EP) 标准品;美拉沙嗪杂质H(EP);美沙拉嗪杂质F;撒酸;沙利西酸;水杨酸,医药级;乙二醇水杨酸酯杂质A(EP);水杨酸;武汉水杨酸生产厂家;水杨酸69-72-7厂家直营
英文名称	Salicylic acid
英文别名	2-Hydroxybenzoic acid;ACIDUM SALICYLICUM;ACETYLSALISYLIC ACID IMP C;ACETYLSALICYLIC ACID IMPURITY C;FEMA 3985;SALICYCLIC ACID;SALICYLIC ACID;RETARDER TSA;Sallcylic acid;2-Hydroxybenzoic Acid [for Biochemical Research];Salicylic acid (2-Hydroxybenzoic acid);SALICYLIC ACID(P);SALICYLIC ACID(P) PrintBack;SALICYLIC ACID(RG);SALICYLIC ACID(RG) PrintBack;Salicylic acid,medicinal;Salicylicacid Solution;2-hydroxy-benzoic acid;Duoplant;Freezone;Ionil;Keralyt;Occlusal;o-hydroxybenzoic acid;phenol-carboxylic acid;Rutranex;Salicylic acid, for analysis ACS;Saligel;Salonil;SAX;Stri-Dex;verrugon;Verrugon;水杨酸;武汉水杨酸生产厂家;2-Carboxyphenol;o-Carboxyphenol;Retarder W;Psoriacid-S-stift;salicylate;Salicylic acid soap;Benzoic acid, 2-hydroxy-;Salicylic acid collodion;Phenol-2-carboxylic acid;Trans-Ver-Sal;Orthohydroxybenzoic acid;2-Hydroxybenzenecarboxylic acid;Acido salicilico;Ionil-Plus;Salicylic acid, tech.;Kyselina salicylova;Clear away wart remover;Duofil
Cas No.	69-72-7
分子式	C₇H₆O₃
分子量	138.12
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性

Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.

性状

Solid

IC50 & Target[1][2]

COX-2
Microbial Metabolite

体外研究(In Vitro)

Salicylic acid is an effective inhibitor of COX-2 activity at concentrations far below those required to inhibit NF-κB (20 mg/mL) activation. Salicylic acid inhibits prostaglandin E2 release when add together with interleukin 1β for 24 hr with an IC50 value of 5 μg/mL, an effect that is independent of NF-κB activation or COX-2 transcription or translation. Salicylic acid acutely (30 min) also causes a concentration-dependent inhibition of COX-2 activity measured in the presence of 0, 1, or 10 μM exogenous arachidonic acid. In contrast, when exogenous arachidonic acid is increased to 30 μM, Salicylic acid is a very weak inhibitor of COX-2 activity with an IC50 of >100 μg/mL. When added together with IL-1β for 24 hr, Salicylic acid causes a concentration-dependent inhibition of PGE2 release with an apparent IC50 value of

体内研究(In Vivo)

In C57Bl/6 DIO mice, Salicylic acid decreases both fasting and postprandial plasma glucose levels. Furthermore, there is a trend to reduce plasma triglyceride levels after Salicylic acid treatment in C57Bl/6 DIO mice (P=0.059). Salicylic acid significantly reduces 11β-HSD1 mRNA in omental adipose tissue in C57Bl/6 DIO mice, with a similar trend in mesenteric adipose (P=0.057). In mesenteric adipose of C57Bl/6 DIO mice, Salicylic acid also reduces 11β-HSD1 enzyme activity.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

ClinicalTrial

结构分类

Phenols
Monopheno

来源

Plants
other fami

溶解度数据	体外研究: DMSO : ≥ 50 mg/mL(362.00 mM) H₂O : 1 mg/mL(7.24 mM;Need ultrasonic) *≥ means soluble, but saturation unknown.

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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