Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.
性状
Solid
IC50 & Target[1][2]
NF-κB, Autophagy
体外研究(In Vitro)
Polydatin protects cerebral cells from ischemic damages via improvement of microcirculation and inhibition of platelet aggregation. In addition, polydatin inhibits ICAM-1 expression in endothelial cells stimulated by lipopolysaccharide; it also attenuates adhesion between white blood cells and endothelial cells. Polydatin inhibits cancer cell proliferation and cell cycle progression. Polydatin induces ER stress-driven cell death.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Polydatin could significantly increase the activity of SOD and the heart rate, attenuate myocardial pathological damage, decrease MDA content, slightly increase arterial pressure and GSH-Px activity, reduce intervals of QRS, QT and ST, and lower FFA content.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature or refrigerated transport.
储存方式
Powder; -20°C; 3 years; 4°C; 2 years;
ClinicalTrial
结构分类
PhenolsPolypheno
来源
Plants
溶解度数据
体外研究:DMSO : ≥ 29 mg/mL(74.29 mM)H2O : 0.1 mg/mL(0.26 mM;Need ultrasonic)*≥ means soluble, but saturation unknown.