Resveratrol.|501-36-0|(白藜芦醇; trans-Resveratrol; SRT501)-陌孚医药/Medlife

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Resveratrol. (Synonyms: 白藜芦醇; trans-Resveratrol; SRT501)

目录号: PC58200 纯度: ≥99%

CAS No. :501-36-0

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中文名称	Resveratrol.
中文别名	白藜芦醇;芪三酚;3,4',5-三羟基芪;(E)-5-[2-(4-羟苯基)-乙烯基]-1,3-苯二酚;白黎芦醇;淫羊藿素;3,4,5-三羟基反式;(E)-3,5,4'-三羟基芪;反式白藜芦醇;Resveratrol 白藜芦醇;Resveratrol 白藜芦醇标准品;白藜芦醇 EP标准品;白藜芦醇 Resveratrol;白藜芦醇虎杖根提取物;白藜芦醇虎杖提;白藜芦醇葡萄皮提取物热销;白藜芦醇（标准品）;白藜芦醇（合成）;白藜芦醇(虎杖提取物);白藜芦醇,Resveratrol,植物提取物,标准品,对照品;白藜芦醇,对照品;白藜芦醇.虎杖苷.薄荷醇.丹皮酚.丹酚酸A.丹酚酸B;白藜芦醇[虎杖提取物];白藜芦醇标准品;白藜芦醇--瑞树专利产品;虎杖甙元;虎杖提取物;虎杖提取物白藜芦醇;葡萄皮提取物;淫羊藿甙;3,4',5-三羟基二苯乙烯;3,4',5-三羟基茋;3,4‘,5-三羟基芪;trans-白藜芦醇,反式-白藜芦醇标准品;白藜芦醇(芪三酚,3,4',5-三羟基芪,虎杖甙元);白藜芦醇.3,4',5-三羟基芪,虎杖甙元;反式-1,2-(3,4',5-三羟基二苯基)乙烯;分析对照品;培利替尼;芪三酚,3,4',5-三羟基芪,(E)-5-[2-(4-羟苯基)-乙烯基]-1,3-苯二酚;茋三酚;3,4′,5-三羟基-反式-二苯乙烯;5-[(1E)-2-(4-羟苯基)乙烯基]-1,3-苯二醇;白藜芦醇，虎杖甙元
英文名称	Resveratrol
英文别名	Resveratrol;trans-3,4,5-Trihydroxystilbene;3,4',5-Trihydroxy-trans-stilbene;5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol;(E)-5-(4-Hydroxystyryl)benzene-1,3-diol;DB0045;Giant Knotweed Extract Trans-Resveratrol;RESVERATROL(P) PrintBack;trans-resveratrol;trans-Resveratrol (SRT-501, RM1812, CA1201, Resvida,Vineatrol 20M, (E)-Resveratrol);3',4,5'-trihydroxy-trans-stilbene;RESVERATROLE;RESVERTROL;trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene;trans-3,5,4'-trihydroxy-stilbene;Veratrum album L alcohol;3,4',5-Stilbenetriol;[ "3,4',5-Stilbenetriol", " 3,4',5-Trihydroxystilbene" ];3,4',5-Trihydroxystilbene;3,5,4'-Trihydroxystilbene;(E)-resveratrol;Resvida;5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol;SRT501;3,5,4'-Trihydroxy-trans-stilbene;Resveratol;5-[(E)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol;3,4',5-trihydroxy-stilbene;Resveratrol, natural;tran
Cas No.	501-36-0
分子式	C₁₄H₁₂O₃
分子量	228.24
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.

性状

Solid

IC50 & Target[1][2]

Adenylyl cyclase
0.8 nM (IC50)IKKβ
1 μM (

体外研究(In Vitro)

Resveratrol (trans-Resveratrol; SRT501) is one of the numerous polyphenolic compounds found in several vegetal sources In the vast majority of cases, Resveratrol displays inhibitory/activatory effects in the micromolar range, which is potentially attainable pharmacologically, although targets with affinities in the nanomolar range have also been reported.
MCF-7 cells are plated in DME-F12 medium supplemented with 5% FBS in the presence of increasing concentrations of Resveratrol. Control cells are treated with the same volume of vehicle only (0.1% ethanol). Resveratrol inhibits the growth of MCF-7 cells in a dose-dependent fashion. Addition of 10 μM Resveratrol results in an 82% inhibition of MCF-7 cell growth after 6 days while at 1 μM, only a 10% inhibition is observed. The cells treated with 10 μM Resveratrol have a doubling time of 60 hr whereas control cells doubled

体内研究(In Vivo)

The average tumor volume is reduced by treatment with Resveratrol (trans-Resveratrol; SRT501) at a dose of 50 mg/kg body weight (195.5±124.8 mm; P<0.05) or 100 mg/kg body weight (81.7±70.5 mm; P<0.001) compare with the vehicle-treated animals (315±94 mm). There is a good correlation between the tumor volume and the tumor mass.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Phenols
Polypheno

溶解度数据	体外研究: DMSO : 100 mg/mL(438.14 mM;Need ultrasonic) Ethanol : 50 mg/mL(219.07 mM;Need ultrasonic) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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