Gnetol|86361-55-9|-陌孚医药/Medlife

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Gnetol

目录号: PC58174 纯度: ≥99%

CAS No. :86361-55-9

商品编号	规格	价格	会员价	是否有货	数量
PC58174-1mg	1mg	询价	询价

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中文名称	Gnetol
中文别名	(E)-2-(3,5-二羟基苯亚烯丙基)苯-1,3-二醇;2,6,3',5'-四羟基二苯乙烯;2-[(1E)2-(3,5-二羟苯基)-乙烯基]-1,3-苯二酚;买麻藤醇
英文名称	Gnetol
英文别名	(E)-2-(3,5-Dihydroxystyryl)benzene-1,3-diol;Gnetol;1,3-Benzenediol,2-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-;2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol;2,3,5,6-tetrahydrothieno[3,4-b][1,4,7]trioxonin;2,3',5',6-tetrahydroxy-trans-stilbene;Thieno[3,4-b]-1,4,7-trioxonin,2,3,5,6-tetrahydro;1,3-Benzenediol, 2-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-;AK109167;3510AC;AX8215340;G0371;5-[(1E)-2-(2,6-dihydroxyphenyl)ethenyl]benzene-1,3-diol
Cas No.	86361-55-9
分子式	C₁₄H₁₂O₄
分子量	244.24
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性	Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities.
性状	Solid
IC50 & Target[1][2]	COX-1 0.78 μM (IC50)Tyrosinase 4.5 μM (IC
体外研究(In Vitro)	The antiproliferative activities of Gnetol are tested in HCT-116, Hep-G2, MDA-MB-231, and PC-3 cell lines by measuring cell viability after treatment with 4.1 μM, 40.9 μM, 204.7 μM, 409.4 μM, and 1023.6 μM. Gnetol shows concentration-dependent reductions in cell viability in cancer cell lines with greatest activity in colorectal cancer. Gnetol at 200 μg/mL significantly offers the highest protection of 54.3% against the toxicant. A lower dose of Gnetol (50 μg/mL) also shields the cell line from the toxic effects of CCl4. The ligand molecule TGF-β and PPARα protein show that Gnetol has the binding affinity of 7.0 and 8.4, respectively.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Male Sprague-Dawley rats were cannulated and dosed either intravenously with Gnetol (10?μg/kg) or orally (100?mg/kg). After oral and intravenous administration, Gnetol is detected in both serum and urine as the parent compound and as a glucuronidated metabolite. The bioavailability of Gnetol is determined to be 6%. Gnetol is rapidly glucuronidated and is excreted in urine and via nonrenal routes. Pretreatment of Male NIH Swiss mice (20-35 g) with Gnetol (50mg/kg, SC) is able to increase the latency period to response in analgesia models.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；
结构分类	Phenols Polypheno
来源	Plants

溶解度数据	体外研究: DMSO : 100 mg/mL(409.43 mM;Need ultrasonic) 配制储存液

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