Genistein.|446-72-0|(染料木素; NPI 031L)-陌孚医药/Medlife

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Genistein. (Synonyms: 染料木素; NPI 031L)

目录号: PC58213 纯度: ≥99%

CAS No. :446-72-0

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中文名称	Genistein.
中文别名	金雀异黄酮;4’,5,7-三羟基异黄酮;5,7-二羟基-3-(4-羟苯基)-4H-1-苯并吡喃-4-酮;染料木因;金雀异黄素;三羟基异黄酮;染料木黄酮;染料木素;4',5,7-三羟基异黄酮;金雀异黄素 USP标准品;芦荟素;染料木素对照品标准品;染料木素标准品;染料木素(AS);染料木素植物提取物,标准品,对照品;4‘,5,7-三羟基异黄酮;染料木素（金雀异黄酮）;5,7,4’-三羟基异黄酮;大豆染料木黄酮;金雀异黄酮标准品;金鹊异黄素;染料木甙元;染料木黄;染料木质素;天然染料木素;46号工业白油;[ "4',5,7-Trihydroxyisoflavone", " 金雀异黄素" ];染料木素，染料木黄酮，金雀异黄酮
英文名称	Genistein
英文别名	Genistein;4’,5,7-trihydroxy-isoflavon;5,7-dihydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;c.i.75610;differenola;genistein(synthetic);genisteol;genisterin;prunetol;5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one;Genistein (4',5,7-Trihydroxyisoflavone);GENISTEIN(AS) PrintBack;GENISTEIN(P) (AHP Verified);GENISTEIN(P) (AHP Verified) PrintBack;GENISTEIN(RG);4',5,7-Trihydroxyisoflavone;5,7,4'-trihydroxyisoflavone;5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;GeniVida;GLYCITEN;sophoricol;4′,5,7-Trihydroxyisoflavone;46# industrial white oil;Bonistein;Genestein;Differenol A;NPI 031L;C.I. 75610;4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-;SIPI 807-1;5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one;4,5,7-Trihydroxyiso-flavone;4',5, 7-Trihydroxyisoflavone;5,7-Dihydroxy-
Cas No.	446-72-0
分子式	C₁₅H₁₀O₅
分子量	270.24
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
性状	Solid
IC50 & Target[1][2]	EGFR 0.6 μM (IC50, Cell Assay)

体外研究(In Vitro)

Genistein inhibits serum-stimulated growth of MCF-7 and T47D ER cells with IC50 values of 7.6 and 8.7 μg/mL by dye exclusion, respectively, and 8.7 and 10.6 μg/mL by [H]thymidmne incorporation, respectively. These values are similar to the IC50 values of 9.4 and 7 μg/mL for MCF-7 and T47D ER cells, respectively, obtained with the MTT assay. Additionally, Genistein at concentrations up to 20 μg/mL does not alter MTT mitochondrial reduction when compared to control cells in an 8 h incubation period. Furthermore, neither biochanin A or daidzein are found to interfere with the MTT assay at IC50 concentrations. Therefore, the MTT assay is valid for determining growth inhibition by Genistein at concentrations under 20 μg/mL in the systems studied.Medlife has not independently confirmed the accuracy o

体内研究(In Vivo)

In the present study, the effective dose of morphine caused a significant decrease in testis weight of mice compared to Saline group (p=0.00). Moreover, testis weight are significantly increase in treated animals with Genistein and Genistein plus morphine in all doses in comparison with morphine group (p=0.028). Morphine caused a significant decrease in the testosterone, LH and FSH hormones compared to saline group (p=0.00). In addition, the testosterone, LH and FSH hormones increased significantly in Genistein (p<0.05) and Genistein plus morphine in all groups administration compared to morphine group (p=0.024). Bisphenol A (BPA) treatment alone and combined with Genistein had no significant effect on the protein expression of LC3II and PPARα in liver of STD- or HFD-fed rats (P>0.05; P>0.05). Significant decreasing of the protein expression of PPARγ in liver is obser

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Flavonoids
Isofla

来源

Plants

溶解度数据	体外研究: DMSO : ≥ 100 mg/mL(370.04 mM) H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) *≥ means soluble, but saturation unknown.

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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