Picropodophyllin|477-47-4|(苦鬼臼毒素; AXL1717; Picropodophyllotoxin; PPP)-陌孚医药/Medlife

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Picropodophyllin (Synonyms: 苦鬼臼毒素; AXL1717; Picropodophyllotoxin; PPP)

目录号: PC57582 纯度: ≥99%

CAS No. :477-47-4

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中文名称	Picropodophyllin
中文别名	苦鬼臼素;IGF-1R 抑制剂;苦鬼臼毒素;岩白菜素
英文名称	Picropodophyllin
英文别名	PPP;Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aS,8aR,9R)-;Picropodophyllotoxin;Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-tri...;Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aS,8aR,9R;IGF-1R Inhibitor, PPP;(-)PPP;AXL 1717;AXL-1717;Picropodophyllin;AXL1717;Picropodophyllin (PPP);AXL1717 (Picropodophyllotoxin);NSC36407;0F35AOI227;C22H22O8;Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5-alpha,5a-alpha,8a-alpha,9-alpha))-;(5R,5aR,8aS,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
Cas No.	477-47-4
分子式	C₂₂H₂₂O₈
分子量	414.41
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC₅₀ of 1 nM.

性状

Solid

IC50 & Target[1][2]

IC50: 1 nM (IGF-1R)

体外研究(In Vitro)

Picropodophyllin (AXL1717) (0.5, 2.5, 10 μM) potently inhibits IGF-1-stimulated IGF-1R, Akt (Ser 473) and Erk1/2 phosphorylation in intact cells. Picropodophyllin (AXL1717) also inhibits cell growth, and induces apoptosis in cultured IGF-1R-positive tumor cells. Picropodophyllin (AXL1717) synergistically sensitizes HMCL, primary human MM and murine 5T33MM cells to ABT-737 and ABT-199 via further decreasing cell viability and enhancing apoptosis. Picropodophyllin and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Picropodophyllin (AXL1717) (20 mg/kg/12 h, i.p.) causes complete tumor regression in SCID mice xenografted with human ES-1, BE, and PC3. Picropodophyllin (AXL1717) shows a potent antitumor activity, increases survival in the 5T33MM mouse model.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Phenylpropanoids

来源

Plants

溶解度数据	体外研究: DMSO : 50 mg/mL(120.65 mM;Need ultrasonic) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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