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Ferulic acid. (Synonyms: 阿魏酸; Coniferic acid)

目录号: PC57592 纯度: ≥99%

CAS No. :1135-24-6

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中文名称	Ferulic acid.
中文别名	阿魏酸;3-(4-羟基-3-甲氧基苯基)-2-丙烯酸;3-(4-羟基-3-甲氧基苯基)2-丙烯酸;4-羟基-3-甲氧基肉桂酸;3-甲氧基-4-羟基桂皮酸;4-羟基3-甲氧基肉桂酸;咖啡酸-3-甲醚;4-羟基-3-甲氧基桂皮酸;3-甲氧基-4-羟基肉桂酸;4-氰基-6-氟吲哚;阿莫西林克拉维酸钾;阿魏酸对照品标准品;阿魏酸 USP标准品;阿魏酸标准品;阿魏酸（合成）;阿魏酸（天然）;阿魏酸,BR;阿魏酸,CP;阿魏酸,植物提取物,标准品,对照品;阿魏酸分析对照品;阿魏酸对照品;阿魏酸钠;安五脂素;合成阿魏酸;天然阿魏酸;(E)-阿魏酸;4-羟基-3-甲氯基肉桂酸;4-羟基-3-甲氧基肉桂酸,咖啡酸-3-甲醚;食品防腐剂;顺式阿魏酸;有机中间体;阿魏酸天然
英文名称	Ferulic acid
英文别名	4-Hydroxy-3-methoxycinnamic acid;Ferulic acid;Forulic acid;(2E)-3-(4-Hydroxy-3-methoxyphenyl)acrylic acid;4-Hydroxy-3-Methoxycinnamic Acid,mixture of cis and trans;Ferulic acid;4-hydroxy-3-methoxy-cinnamic acid;conifericacid;ferulaic acid;FERULIC ACID pure;Ferulic acid,matrix substance for MALDI-MS;Ferulic?acid;FERULLIC ACID;Fumalic acid;WAKO068-04821;3-Methoxy-4-hydroxy-cinnamic acid;3-(4-Hydroxy-3-methoxyphenyl)acrylic acid;orulic acid;trans-Ferulic Acid;trans-4-Hydroxy-3-methoxycinnamic acid;(E)-Ferulic acid;ferulate;Coniferic acid;2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-;Ferulic acid, trans-;(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid;3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid;Cinnamic acid, 4-hydroxy-3-methoxy-;3-methoxy-4-hydroxycinnamic acid;(E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propeno
Cas No.	1135-24-6
分子式	C₁₀H₁₀O₄
分子量	194.18
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

性状

Solid

IC50 & Target[1][2]

FGFR1
3.78 μM (IC50)FGFR2
12.5 μM (IC

体外研究(In Vitro)

Ferulic acid (FA) is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively. Ferulic acid exhibits great inhibitory activity on FGFR1 with an inhibitory rate of 92% at 1 μM. The proliferation of HUVEC stimulated by FGF1 is markedly decreased after Ferulic acid treatment ranging from 5 to 40 μM for 24 h. Ferulic acid does not exert significant cell viability up to 20 μM, but over 30 μM Ferulic acid exhibits a cytotoxic effect in HUVEC compare to the control. Ferulic acid inhibits FGF1-induced HUVEC migration and invasion in a dose-dependent manner. Ferulic acid markedly suppresses the FGF1-induced phosphorylation of PI3K and Akt. Ferulic acid treatments significantly inhibit MMP-2 and MMP-9 expression stimulated by FGF1.Medlife has not independen

体内研究(In Vivo)

Treatment with Ferulic acid (FA) potently inhibits FGF1-induced neovascularization. It is found that intragastric administration of Ferulic acid markedly inhibits tumor volume and tumor weight, as compare to the counterparts treated with DMSO.Furthermore, Ferulic acid treatment is well tolerated, and there is no significant difference in weight between the vehicle group and the FA-treated groups. Ferulic acid (0.01, 0.1, 1 or 10 mg/kg) given by oral route decreases significantly the immobility time in the forced swimming test (FST) and tail suspension test (TST), whereas produces no effect in the open-field test. Results demonstrate that the administration of Ferulic acid (0.001 mg/kg, p.o.) boosts the antidepressant-like effect of fluoxetine (5 mg/kg, p.o.) in the TST.Medlife has not independently confirmed the accuracy of

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Phenylpropanoids

来源

Plants
other fami

溶解度数据	体外研究: DMSO : 100 mg/mL(514.99 mM;Need ultrasonic) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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