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Caffeic acid (Synonyms: 咖啡酸)

目录号: PC57591 纯度: ≥99%

CAS No. :331-39-5

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中文名称	Caffeic acid
中文别名	3,4-二羟基肉桂酸;3-(3,4-二羟苯基)-2-丙烯酸;3,4-二羟基苯丙烯酸;β-(3,4-二羟苯基)丙烯酸;3-（3,4-二羟基苯基）丙烯酸;水解咖啡鞣酸;3,4-二羥桂皮酸;3,4-二羟基苯乙烯酸;二羟基桂皮酸;甲萘氢醌二磷酸酯钠;咖啡酸标准品;咖啡酸(RG);咖啡酸（标准品）;咖啡酸, 反式为主;咖啡酸植物提取物,标准品,对照品;咖啡酸,分析标准品;小柴胡提取物;咖啡酸;水解咖啡鞣酸,3,4-二羟基肉桂酸;咖啡酸 ;(E)-3,4-二羟基肉桂酸;咖啡酸(3,4-二羟基肉桂酸)
英文名称	Caffeic acid
英文别名	3-(3,4-Dihydroxyphenyl)acrylic acid;3-(3,4-DIHYDROXYPHENYL)-2-PROPENOIC ACID;AKOS B004050;CAFFEIC ACID;RARECHEM BK HC T335;TIMTEC-BB SBB006475;(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoic acid;2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-;3-(3,4-dihydroxyphenyl)-2-propenoicaci;3-(3,4-Dihydroxyphenyl)propenoic acid;3,4-dihydroxybenzeneacrylicacid;3,4-dihydroxy-cinnamicaci;3,4-dihydroxycinnamicacid,predominantlytransisomer;4-(2’-carboxyvinyl)-1,2-dihydroxybenzene;4-(2-Carboxyethenyl)-1,2-dihydroxybenzene;4-(2'-Carboxyvinyl)-1,2-dihydroxybenzene;3,4-Dihydroxycinnamic acid;CAFFEIC ACID(P) (AHP Verified);CAFFEIC ACID(P) (AHP Verified) PrintBack;Caffeic acid;3,4-dihydroxyben;Caffeic;CaffeicAcidPure;CAFFIC ACID;(E)-3,4-Dihydroxycinnamic Acid;[ "" ];咖啡酸;3,4-Dihydroxybenzeneacrylic acid;Caffeic acid(3,4-dihydroxycinnamicacid);cis-caffeic acid
Cas No.	331-39-5
分子式	C₉H₈O₄
分子量	180.16
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).
性状	Solid
IC50 & Target[1][2]	5-LO

体外研究(In Vitro)

Caffeic acid has inhibitory effects on histamine-induced responses and the inhibitory effect of Caffeic acid is gradually increased when the concentration used for pretreatment is increased from 0.1 to 1 mM, similar to typical dose-dependent responses. Pretreatment of HEK293T-TRPV1 cells with 1 mM Caffeic acid results in significant inhibition of capsaicin-induced responses. When lower concentration of Caffeic acid is used, the inhibitory effect for capsaicin-induced responses is less evident. Calcium imaging experiments show that Caffeic acid incubation results in significant inhibition in histamine-sensitive dorsal root ganglion (DRG) neurons. Pretreatment with Caffeic acid (1 mM) results in a significant decrease in the percentage of responsive DRG neurons to histamine application from 12.5% to 2.1%. Pretreatment with 1 mM Caffeic acid dramatically blocks the allylisothiocy

体内研究(In Vivo)

Mice pretreated with Caffeic acid (500 mg/kg) exhibit significantly less histamine-induced scratching (30.50±10.87 bouts/1 h, n=6). It is further found that the lower dose of Caffeic acid (100 mg/kg) is not significantly effective in terms of anti-scratching effects in histamine-induced scratching, although there appears to be a tendency of reduction (49.40±12.35 bouts/1 h, n=5). The chloroquine induced scratching is significantly inhibited by pretreatment with 500 mg/kg of Caffeic acid (161.6±31.42 bouts/1 h, n=5).Caffeic acid significantly reduces the expression of 5-LO mRNA (P<0.01) dose-dependently in hippocampus. Compare with the ischemia-reperfusion (I/R) non-treated group, 5-LO protein expression is significantly reduced in the I/R-Caffeic acid group (P<0.05 or P<0.01), especially in the I/R-Caffeic acid group (50 mg/kg). Compare with the I/R non-treated group,

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Phenylpropanoids

来源

Plants
other fami

溶解度数据	体外研究: DMSO : 100 mg/mL(555.06 mM;Need ultrasonic) H₂O : < 0.1 mg/mL (ultrasonic) (insoluble) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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