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艾莎康唑 (Synonyms: 艾沙康唑; BAL-4815; RO-0094815)

目录号: PC22021 纯度: 98%

CAS No. :241479-67-4

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中文名称	艾莎康唑
中文别名	艾沙康唑;艾沙康挫;Isavuconazole艾沙康唑;(1-乙基丁基)胺;艾沙康唑-D4;艾沙康唑-活性化合物;艾莎康唑
英文名称	Isavuconazole
英文别名	Isavuconazole;4-[2-[(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile;Isavuconazol;Isavuconazonium;Bal4815;BAL-4815;FK463;Micafungin sodium;RO-0094815;UNII-60UTO373KE;4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile;BAL 4815;Isavuconazole [INN];60UTO373KE;RO 0094815;Isavuconazole (INN);4-[2-[(1R,2R)-2-(2,5-difluorophenyl)-2-hydroxy-1-methyl-3-(1,2,4-triazol-1-yl)pro
Cas No.	241479-67-4
分子式	C₂₂N₅OF₂SH₁₇
分子量	437.47
包装储存	Powder: -20°C for 3 years In solvent: -80°C for 2 years

性状	Powder
运输条件	-20℃
储存方式	Powder: -20°C for 3 years In solvent: -80°C for 2 years
描述&特点	SP2509 activity assays: Test compounds are diluted to 20 × the desired test concentration in 100% DMSO and 2.5?μL of the diluted drug sampleis added to a black 384-well plate. The LSD1 enzyme stock is diluted 17-fold with assay buffer and 40?μL of the diluted LSD1 enzyme is added to the appropriate wells. Substrate, consisting of horseradish peroxidase, dimethyl K4 peptide corresponding to the first 21 amino acids of the N-terminal tail of histone H3, and 10-acetyl-3,7-dihydroxyphenoxazine is then added to wells. Resorufin is analyzed on an Envision plate reader with an excitation wavelength of 530?nm and an emission wavelength of 595?nm. The activity of SP2509 on the other oxidases is determined by using commercially available kits. The glucose oxidase activity (which also noncovalently binds FAD in an elongate conformation), is determined using the glucose oxidase kit. The MAO assays are performed using the MAO-glo kit with MAO-A and MAO-B.
参考文献	[1]Lau S K P, Xing F, Tsang C C, et al. Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China[J]. Mycoses. 2019 May;62(5):450-457. [2]Seifert H, et al. Antimicrob Agents ChemOthers. 2007 May;51(5):1818-21. [3]Tsang C C, Tang J Y M, Ye H, et al. Rare/cryptic Aspergillus species infections and importance of antifungal susceptibility testing[J]. Mycoses. 2020, 63(12): 1283-1298. [4]Tsang C C, Chan K F, Chan W, et al. Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing[J]. Emerging Microbes & Infections. 2020: 1-53. [5]Tsang C C, Tang J Y M, Chan K F, et al. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing[J]. Emerging microbes & infections. 2019;8(1):531-541.

溶解度数据	DMSO:70 mg/mL (160.01 mM)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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