Orotic acid|65-86-1|(乳清酸; 6-Carboxyuracil; Vitamin B13)-陌孚医药/Medlife

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Orotic acid (Synonyms: 乳清酸; 6-Carboxyuracil; Vitamin B13)

目录号: PC10334 纯度: ≥98%

CAS No. :65-86-1

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PC10334-500mg	500mg	¥490.00	请登录
PC10334-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥490.00	请登录

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中文名称

Orotic acid

中文别名

乳清酸;辣-4-甲酸;尿嘧啶羧酸;脲嘧啶-6-羧酸;维生素B13;无水乳清酸;纯天然鸡肝粉;乳清酸标准品;乳清酸,BR;乳清酸维生素类药;维生素B13(乳清酸);维生素B13、乳清酸;1,2,3,6-四氢-2,6-二氧-4-嘧啶羧酸;1,2,3,6-四氢-2,6-二氧代-4-嘧啶羧酸;4-羧酸;6-羧酸;尿嘧啶-6-羧酸;維生素B13;康宁培养基551

英文名称

Orotic acid

英文别名

2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid;orotic acid anhydrous;orotic acid free acid anhydrous plant*cell cultur;1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid;2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid~Uracil-4-carboxylic acid;2,4-Dioxy-6-carboxy pyrimidine;2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid;4-pyrimidinecarboxylic acid;Orotic acid;OROTIC ACID FREE ACID ANHYDROUS;URACIL-6-CARBOXYLIC ACID(P);[3H]-Orotic acid;1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine carboxylic acid;6-Carboxyuracil;6-uracilic acid;H-ORO-OH;Orodin;orodin[qr];Oropur;orotic;Orotonin;Orotonsan;Orotsaure;Oroturic;Orotyl;Vitamin B13;2,6-Dihydroxypyrimidine-4-carboxylic acid;6-Carboxy-2,4-dihydroxypyrimidine;Uracil-6-carboxylic acid;KBM551, serum-free medium for DC and CIK DC/CIK;1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid;Whey factor;6-Uracilcarboxylic acid;Animal galactose factor;Orotsaeure;Molkensaeure;Uracil-6-carbosaeure;orotate;4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-;2,6-Dihydroxy-4-pyrimidinecarboxylic acid;Orotsaeure [German];Acidum oroticum;Acide orotique;Acido orotico

Cas No.

65-86-1

分子式

C₅H₄N₂O₄

分子量

156.10

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats.

性状

Solid

IC50 & Target[1][2]

Human Endogenous Metabolite

体外研究(In Vitro)

Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD).
Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

ClinicalTrial

结构分类

Ketones, Aldehydes, Acids

参考文献

[1]. L?ffler M, et, al. Orotate (orotic acid): An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids. [Information]

[2]. Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15. [Information]

[3]. Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr;110(4):816-21. [Information]

溶解度数据

体外研究:

DMSO : 55 mg/mL (352.34 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.4061 mL	32.0308 mL	64.0615 mL
5 mM	1.2812 mL	6.4061 mL	12.8123 mL
10 mM	0.6406 mL	3.2031 mL	6.4061 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.75 mg/mL (17.62 mM); Clear solution

此方案可获得 ≥ 2.75 mg/mL (17.62 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 27.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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