2-Hydroxy-3-methylbutanoic acid|4026-18-0|(2-羟基-3-甲基丁酸)-陌孚医药/Medlife

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2-Hydroxy-3-methylbutanoic acid (Synonyms: 2-羟基-3-甲基丁酸)

目录号: PC19233 纯度: ≥98%

CAS No. :4026-18-0

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中文名称	2-Hydroxy-3-methylbutanoic acid
中文别名	2-羟基-3-甲基丁酸;2-羟基异戊酸
英文名称	2-Hydroxy-3-methylbutanoic acid
英文别名	2-Hydroxy-3-methylbutanoic acid;2-Hydroxy-3-Methylbutyric Acid;2-hydroxy-3-methyl-butanoic acid;2-Hydroxy-3-methyl-butyric acid;C5H10O3;2-HYDROXY-3-METHYLBU;2-HYDROXYISOVALERIC ACID;2-Oxyisovaleric Acid;A-HYDROXYISOVALERIC ACID;Einecs 223-697-5;L-2-hydroxyisovaleric acid;alpha-hydroxyisovaleric acid;L-Valic acid;D-Valic acid;Butanoic acid, 2-hydroxy-3-methyl-;3-Methyl-2-hydroxybutyric acid;alpha-hydroxyisovalerate;2-Hydroxyisopentanoic acid;(RS)-2-hydroxyisovaleric acid;2-Oxyisovalerate;NGEWQZIDQIYUNV-UHFFFAOYSA-N;2-Hydroxyisovalerate;A-hydroxyisovalerate;2-Hydroxyisopentanoate;DL-a-hydroxyisovalerate;DL-2-Hydroxyisovalerate;DL-alpha-hydroxyisov
Cas No.	4026-18-0
分子式	C₅H₁₀O₃
分子量	118.13
包装储存	Powder： -20°C 3 years; 4°C 2 years; In solvent: -80°C 6 months; -20°C 1 month

生物活性	2-Hydroxy-3-methylbutanoic acid is a close structure analogue of GHB, which is a naturally occurring neurotransmitter and a psychoactive agent.
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite
运输条件	常温运输或冷藏运输。
储存方式	Powder： -20°C 3 years; 4°C 2 years; In solvent: -80°C 6 months; -20°C 1 month
描述&特点	2-Hydroxy-3-methylbutyric acid (2-hydroxyisovaleric acid) is a metabolite found in the urine of patients with phenylketonuria, methylmalonic acidemia, propionic acidemia, 3-ketothiolase deficiency, isovaleric acidemia, 3-methylcrotonylglycemia, 3-hydroxy-3-methylglutaric acidemia, multiple carboxylase deficiency, glutaric aciduria, ornithine transcarbamylase deficiency, glyceroluria, tyrosinemia type I, galactosemia, and maple syrup urine disease.
结构分类	Ketones, Aldehydes, Acids
参考文献	[1]. Pan YM, et al. Improved procedure for the analysis of gamma-hydroxybutyrate and ethylene glycol in whole blood. J Anal Toxicol. 2001 Jul-Aug;25(5):328-32. [2].Magni F, et al. Simultaneous determination of plasma levels of alpha-ketoisocaproic acid and leucine and evaluation of alpha-[1-13C]ketoisocaproic acid and [1-13C]leucine enrichment by gas chromatography-mass spectrometry. Anal Biochem. 1994 Aug 1;220(2):308-14.

溶解度数据	DMSO : 100 mg/mL (846.53 mM; Need ultrasonic) DMSO: 194.7 mM( < 1 mg/mL refers to the product slightly soluble or insoluble )

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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