S 32826|1103672-43-0|-陌孚医药/Medlife

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S 32826

目录号: PC15225 纯度: ≥98%

CAS No. :1103672-43-0

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中文名称	S 32826
中文别名	3,7-二氢-1-(5-羟基己基)-3,7-二(三氘甲基)-1H-嘌呤-2,6-二酮
英文名称	S 32826
英文别名	S 32826
Cas No.	1103672-43-0
分子式	C₂₁H₃₆NO₄P
分子量	397.49
包装储存	-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

生物活性

S32826 disodium is a potent autotaxin inhibitor, with an IC₅₀ of 8.8 nM. S32826 disodium shows similar inhibitory effects at various autotaxin isoforms (α, β and γ). S32826 disodium inhibits LPA release from adipocytes.

性状

Solid

IC50 & Target[1][2]

Autotaxin

8.8 nM (IC₅₀)

体外研究(In Vitro)

S32826 (0.001-10 μM; 10 days) disodium dose-dependently inhibits the release of lyso-phosphatidic acid (LPA) by 3T3-F442A adipocytes with an IC₅₀ of 90 nM and a maximal inhibition of 80% at 500 nM.
S32826 (1 μM; 24 h) disodium inhibits Dexamethasone-induced increases in autotaxin (ATX) mRNA expression in HTM cells and lysoPLD activity in conditioned media. S32826 disodium inhibits Dexamethasone-induced the phosphorylation of MLC and cofilin, mRNA upregulation of COL1A1 and COL4A1, and expression of α-SMA, fibronectin and collagen-1 in the HTM cells.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Topical application of S32826 (2-10 mM; 2 h-5 d) disodium decreases intraocular pressure (IOP) in a dose- and time-dependent manner in rabbits.
S32826 (～2 μM; single intracameral injection) disodium reduces the IOP in rabbits, with the ocular hypotensive response lasting for more than 48 hrs.
S32826 (10 mg/kg; p.o., i.p., s.c., and i.v.) disodium shows poor in vivo stability and/or bioavailability.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献

[1]. Ferry G, et, al. S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool. J Pharmacol Exp Ther. 2008 Dec;327(3):809-19. [Information]

[2]. Honjo M, et, al. Role of the Autotaxin-LPA Pathway in Dexamethasone-Induced Fibrotic Responses and Extracellular Matrix Production in Human Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):21-30. [Information]

[3]. Iyer P, et, al. Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure. PLoS One. 2012;7(8):e42627. [Information]

溶解度数据

体外研究:

Ethanol : 2.4 mg/mL (5.44 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2653 mL	11.3263 mL	22.6526 mL
5 mM	0.4531 mL	2.2653 mL	4.5305 mL
10 mM	---	---	---

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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