Sodium citrate|68-04-2|(枸椽酸钠; Sodium citrate; Trisodium citrate anhydrous)-陌孚医药/Medlife

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Sodium citrate (Synonyms: 枸椽酸钠; Sodium citrate; Trisodium citrate anhydrous)

目录号: PC15217 纯度: ≥98%

CAS No. :68-04-2

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中文名称	Sodium citrate
中文别名	柠檬酸三钠;柠檬酸钠,二水;柠檬酸三钠盐二水合物;二水柠檬酸钠;二水柠檬酸三钠;柠檬酸钠;柠檬酸钠(无水);柠檬酸三钠盐;柠檬酸钠,无水;无水柠檬酸钠;枸椽酸钠;枸橼酸钠;柠檬酸三钠,AR;柠檬酸三钠,Cp;食品级柠檬酸钠;四合一磷化液;无水柠檬酸三钠;油性树脂色浆;2-羟基丙烷-1,2,3-三羧酸;柠檬酸三纳;柠檬酸盐浓缩液;食品级无水柠檬酸钠;68-04-2
英文名称	Sodium citrate
英文别名	Sodium 2-hydroxypropane-1,2,3-tricarboxylate;anhydrous Sodium Citrate;trisodium 2-hydroxypropane-1,2,3-tricarboxylate anhydrous;Sodium citrate;trisodium citrate anhydrous;Trisodium citrate dihydrate;Citric acid trisodium salt;anhydrous trisodium citrate;citnatin;citreme;Citric acid;Citric acid 3Na;citrosodina;citrosodine;citrosodna;FEMA 3026;Na3-citrate;natrocitral;Sodium citrate, anhydrous;Trisodium citrate;2-Hydroxy-1,2,3-propanetricarboxylic acid trisodium salt;Sodium citrate anhydrous;Trisodium citrate, anhydrous;Citric acid, trisodium salt;1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt;FEMA No. 3026;Sodium citrate (Na3C6H5O7);RS7A450LGA
Cas No.	68-04-2
分子式	C₆H₅Na₃O₇
分子量	258.07
包装储存	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice.

性状

Solid

IC50 & Target[1][2]

Human Endogenous Metabolite

体外研究(In Vitro)

Citric acid trisodium (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner.
Citric acid trisodium (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.
Citric acid trisodium (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	HaCaT cells
Concentration:	0, 2.5, 5, 7.5, 10, 12.5 mM
Incubation Time:	24 h
Result:	Inhibited the cell viability in a dose dependent manner.

Cell Cycle Analysis

Cell Line:	HaCaT cells
Concentration:	12.5 mM
Incubation Time:	0, 12, 24, 48, 72 h
Result:	Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.

Western Blot Analysis

Cell Line:	HaCaT cells
Concentration:	12.5 mM
Incubation Time:	12, 24, 48 h
Result:	Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl.

体内研究(In Vivo)

Citric acid trisodium (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver.
Citric acid trisodium (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes.
Citric acid trisodium (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	20 g male Kunming mice
Dosage:	120, 240, 480 mg/kg
Administration:	I.p.; weekly for 3 weeks
Result:	T-SOD and GSH-Px activities in the treated groups decreased with increasing doses of citric acid, NOS activity tended to increase, and H2O2 and MDA contents gradually decreased.

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82. [Information]

[2]. Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90(1):38-44. [Information]

[3]. Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20. [Information]

溶解度数据

体外研究:

H₂O : 100 mg/mL (387.49 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.8749 mL	19.3746 mL	38.7492 mL
5 mM	0.7750 mL	3.8749 mL	7.7498 mL
10 mM	0.3875 mL	1.9375 mL	3.8749 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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