Title：The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells

标题：乳酸和乙醇酸对黑色素瘤细胞合成黑色素的抑制作用

Authors:Usuki A., Ohashi A., Sato H., et al.

作者：Usuki A., Ohashi A., Sato H. 等

Journal:Experimental Dermatology, 2003, Volume 12, Supplement 2, Pages 43-50

期刊：《实验皮肤病学》，2003年，第12卷，增刊2，第43-50页

Summary:

This study examines the effects of glycolic acid and lactic acid on melanin synthesis in melanoma cells. Melanin synthesis, regulated by the enzyme tyrosinase, plays a critical role in skin pigmentation. Overproduction of melanin can lead to hyperpigmentation disorders.

摘要：

本研究探讨了糖醇酸和乳酸对黑素瘤细胞黑素合成的影响。黑素合成由酪氨酸酶调节，酪氨酸酶在皮肤色素形成中起着至关重要的作用。黑素过度生成可能导致色素沉着障碍。

Key Findings:

1.Glycolic Acid (GA):

CAS Number: 79-14-1

Inhibits melanin synthesis by interfering with the activity of tyrosinase.

The study showed that GA significantly reduced melanin content in treated melanoma cells compared to untreated controls.

2.Lactic Acid (LA):

CAS Number: 50-21-5

Also demonstrated an inhibitory effect on melanin synthesis.

LA's effect was slightly less potent than GA but still significant.

1.Mechanism:

Both acids reduce melanin production by inhibiting tyrosinase activity, which is essential for melanin synthesis.

The inhibitory effect was observed to be dose-dependent, meaning higher concentrations of the acids resulted in greater inhibition.

2.Applications:

These findings suggest potential use of GA and LA in treating hyperpigmentation disorders, such as melasma and age spots.

The study provides a basis for developing skin-whitening agents that can be used in dermatological treatments.

主要发现：

1.糖醇酸（GA）：

CAS号: 79-14-1

通过干扰酪氨酸酶的活性抑制黑素合成。

研究表明，与未处理的对照组相比，GA显著降低了处理过的黑素瘤细胞中的黑素含量。

2.乳酸（LA）：

CAS号: 50-21-5

同样显示出对黑素合成的抑制作用。

LA的效果略低于GA，但仍然显著。

机制：

这两种酸通过抑制黑素合成所必需的酪氨酸酶活性来减少黑素生成。

研究观察到抑制效果与剂量相关，即较高浓度的酸导致更强的抑制作用。

应用：

这些发现表明GA和LA在治疗色素沉着障碍（如黄褐斑和老年斑）方面的潜在用途。

(该研究为开发可用于皮肤美白剂的皮肤科治疗提供了基础。