Authors: Ricardo G. Correa, et al.
Journal: Chemistry & Biology
Publication Date: July 29, 2011
Volume: 18
Pages: 825-832
DOI: 10.1016/j.chembiol.2011.06.009
摘要
本研究报告了针对NOD1的2-氨基苯并咪唑衍生物的发现和表征。这些化合物通过高通量筛选和化学优化获得,并在生物化学和细胞模型中展示了选择性和效力。
Abstract: This study reports the discovery and characterization of 2-aminobenzimidazole derivatives as selective inhibitors of NOD1. These compounds were obtained through high-throughput screening and chemical optimization, showing selectivity and potency in biochemical and cellular models.
背景
NOD1是一种在免疫反应中起重要作用的蛋白质。选择性抑制NOD1可能对治疗多种炎症和免疫相关疾病具有潜在价值。
Background: NOD1 is a protein that plays an important role in immune responses. Selective inhibition of NOD1 has potential value in treating various inflammatory and immune-related diseases.
方法
研究团队通过高通量筛选和化学优化,发现了几种2-氨基苯并咪唑衍生物,并评估了它们作为NOD1抑制剂的选择性和效力。
Methods: The research team identified and optimized several 2-aminobenzimidazole derivatives through high-throughput screening and chemical optimization, evaluating their selectivity and potency as NOD1 inhibitors.
结果
所发现的2-氨基苯并咪唑衍生物在生物化学和细胞模型中表现出对NOD1的选择性抑制作用,并通过结晶学研究确认了其结合模式。
Results: The identified 2-aminobenzimidazole derivatives showed selective inhibition of NOD1 in biochemical and cellular models, with their binding modes confirmed by crystallography studies.
结论
该研究成功开发了几种2-氨基苯并咪唑衍生物作为选择性NOD1抑制剂,这些化合物有望用于治疗炎症和免疫相关疾病。
Conclusion: This study successfully developed several 2-aminobenzimidazole derivatives as selective NOD1 inhibitors, which hold promise for the treatment of inflammatory and immune-related diseases.
主要化合物
以下是该研究中提到的几个关键化合物及其对应的CAS号:
1. 化合物A (Compound A)
CAS号: 799264-47-4