Title：Discovery and Characterization of 2-Aminobenzimidazole Derivatives as Selective NOD1 Inhibitors

标题：发现和表征2-氨基苯并咪唑衍生物作为选择性NOD1抑制剂

Authors: Ricardo G. Correa, et al.

Journal: Chemistry & Biology

Publication Date: July 29, 2011

Volume: 18

Pages: 825-832

DOI: 10.1016/j.chembiol.2011.06.009

摘要

本研究报告了针对NOD1的2-氨基苯并咪唑衍生物的发现和表征。这些化合物通过高通量筛选和化学优化获得，并在生物化学和细胞模型中展示了选择性和效力。

Abstract: This study reports the discovery and characterization of 2-aminobenzimidazole derivatives as selective inhibitors of NOD1. These compounds were obtained through high-throughput screening and chemical optimization, showing selectivity and potency in biochemical and cellular models.

背景

NOD1是一种在免疫反应中起重要作用的蛋白质。选择性抑制NOD1可能对治疗多种炎症和免疫相关疾病具有潜在价值。

Background: NOD1 is a protein that plays an important role in immune responses. Selective inhibition of NOD1 has potential value in treating various inflammatory and immune-related diseases.

方法

研究团队通过高通量筛选和化学优化，发现了几种2-氨基苯并咪唑衍生物，并评估了它们作为NOD1抑制剂的选择性和效力。

Methods: The research team identified and optimized several 2-aminobenzimidazole derivatives through high-throughput screening and chemical optimization, evaluating their selectivity and potency as NOD1 inhibitors.

结果

所发现的2-氨基苯并咪唑衍生物在生物化学和细胞模型中表现出对NOD1的选择性抑制作用，并通过结晶学研究确认了其结合模式。

Results: The identified 2-aminobenzimidazole derivatives showed selective inhibition of NOD1 in biochemical and cellular models, with their binding modes confirmed by crystallography studies.

结论

该研究成功开发了几种2-氨基苯并咪唑衍生物作为选择性NOD1抑制剂，这些化合物有望用于治疗炎症和免疫相关疾病。

Conclusion: This study successfully developed several 2-aminobenzimidazole derivatives as selective NOD1 inhibitors, which hold promise for the treatment of inflammatory and immune-related diseases.

主要化合物

以下是该研究中提到的几个关键化合物及其对应的CAS号：

1. 化合物A (Compound A)
   CAS号: 799264-47-4